Figure 5

Changes of ANXA2, ATP1A3, NRGN, and PVALB mRNAs in motor cortex of SALS subjects. In-situ hybridization analysis of ANXA2, ATP1A3, NRGN, and PVALB mRNAs was performed in duplicate tissue sections of motor cortex from five control and five SALS subjects. Optical density values were normalized against those obtained in control subjects and subjected to two-tailed Student's t-test (with the P values 3.44e-6 (ANXA2), 7.91e-3 (ATP1A3), 2.29e-5 (NRGN) and 2.88e-6 (PVALB), respectively, diseased vs. control). The bar graph shows mean results and the standard deviation of the mean of labeling in control and SALS subjects.