Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis

Table 1 Characteristics of subjects

Sample ID	Sample Type	Order Code	Chief Disease	Cause of Death	Age [years/days]	Gender	Race	PMI [h]
Control 1	tissue	BTB3428 ^A	drowning	drowning	56/275	Female	Caucasian	17
Control 2	tissue	BTB3576^A	hypertension	ruptured abdominal aortic aneurism	59/260	Male	Caucasian	15
Control 3	tissue	BTB3577^A	n/a	n/a	59/118	Male	Caucasian	21
Control 4	tissue	BTB3688^A	ascending colon adenocarcinoma	ascending colon adenocarcinoma	60/-	Male	Hispanic White	17
Control 5	tissue	HCtAN^A	n/a	n/a	72/-	Male	Caucasian	11
Control 6	tissue	HCtAV^A	n/a	n/a	84/-	Female	Caucasian	2.75
Control 7	tissue	HCtEU^A	coronary artery disease	n/a	79/-	Female	Caucasian	7.5
Control 8	tissue	HCtFM^A	n/a	n/a	70/-	Female	Caucasian	8.5
Control 9	RNA	6782^B	thrombosis and coronary atherosclerosis	heart attack	68/-	Male	Caucasian	n/a
Diseased 1	tissue	BTB3226 A	ALS	respiratory failure with probable early pneumonia	71/18	Male	Caucasian	19
Diseased 2	tissue	BTB3235 A	ALS	respiratory failure	73/106	Male	Caucasian	5.5
Diseased 3	tissue	BTB3461 A	ALS	ALS	77/53	Male	Caucasian	7.5
Diseased 4	tissue	BTB3580^A	ALS	respiratory failure	58/83	Male	Caucasian	22
Diseased 5	tissue	BTB3583^A	ALS	respiratory distress	52/54	Female	Hispanic White	20.5
Diseased 6	tissue	BTB3590^A	ALS	pneumonia	75/-	Male	Caucasian	24
Diseased 7	tissue	BTB3603^A	ALS	N/A	67/325	Female	Caucasian	17
Diseased 8	tissue	BTB3611^A	ALS	N/A	69/90	Female	Caucasian	13
Diseased 9	tissue	BTB3689^A	ALS	N/A	61/141	Female	Caucasian	22
Diseased 10	tissue	BTB3713^A	ALS	ALS	66/252	Male	Caucasian	13
Diseased 11	RNA	6166^B	ALS	respiratory failure	70/-	Male	Caucasian	n/a

20 motor-cortex samples of eleven ALS patients and nine controls were analyzed on individual Whole Human Genome Arrays for genome-wide expression profiling. Age, gender, race, and post-mortem interval (mean controls 12.47 ± 6.06 h and mean patients 16.35 ± 6.37 h, P = 0.21) are shown for all tissue samples. A – Miami Brain and Tissue Bank for Developmental Disorders; B – Ambion, Inc.; n/a – not available

ISSN: 1471-2164