Table 1 Genes differentially expressed in the transcriptome data as a result of bldA mutation¹

SCO0072

possible secreted protein

N/A

0.055*

down

Secreted

SCO0247

conserved hypothetical protein

3.29E-06

N/A

down

Predicted 1 transmembrane domain

SCO0248

hypothetical protein

1.76E-05

N/A

down

Predicted pI = 11.6

SCO0297

secreted protein

8.25E-05

0.033

down

Secreted

SCO0472

possible secreted protein

N/A

0.076*

down

Secreted

SCO0499

possible formyltransferase

9.76E-04

N/A

down

SCO0759

hypothetical protein

0.000976

N/A

down

Predicted 1 transmembrane domain

SCO0760

probable methyltransferase

0.000796

0.083

down

Predicted pI = 10.9

SCO0762

protease inhibitor precursor

0.0262

0.012

down

Secreted

SCO0990

integral membrane protein

7.72E-03

N/A

down

Predicted 7 transmembrane domains

SCO0991

conserved hypothetical protein

0.00772

N/A

down

Predicted transmembrane domain

SCO0994

integral membrane protein

0.0317

N/A

down

Predicted 9 transmembrane domains

SCO0995

probable methyltransferase

9.76E-04

N/A

down

Predicted 2 transmembrane domains

SCO1089

unknown

N/A

0*

up

None

SCO1815

probable 3-oxacyl-(acyl-carrier-protein) reductase

N/A

0.084*

down

Predicted 2 transmembrane domains

SCO1845

possible low-affinity phosphate transport protein

N/A

0*

up

Predicted 10 transmembrane domains

SCO1968

probable secreted hydrolase

N/A

0*

down

Secreted

SCO2435

hypothetical protein

0.00589

N/A

down

None

SCO3088

hypothetical protein

0.000415

N/A

up

Predicted pI = 9.7, mwt = 8377 Da

SCO3285

large gly/ala rich protein

7.72E-03

N/A

up

SCO3286

secreted protein

0.00772

0.05

up

Secreted

SCO3428

50S ribosomal protein

N/A

0.082*

down

Predicted pI = 10.8, mwt = 6416 Da

SCO3608

hypothetical protein

N/A

0.1*

up

Predicted 3 transmembrane domains

SCO3717

probable cation transport system component

N/A

0.068

up

Predicted 7 transmembrane domains

SCO3718

probable cation transport system component

N/A

0

up

Predicted 11 transmembrane domains

SCO4131

integral membrane protein

0.0389

N/A

down

Predicted 2 transmembrane domains

SCO4173

unknown

N/A

0.088*

down

Predicted 1 transmembrane domains

SCO4174

possible integral membrane protein

N/A

0.088*

down

Predicted 1 transmembrane domains; predicted pI = 11.0

SCO4187

putative membrane protein

0.0404

0.1

down

Predicted pI = 9.5, mwt = 6268 Da

SCO4246

hypothetical protein

5.89E-03

N/A

down

Predicted pI = 9.7

SCO4252

hypothetical protein

3.29E-06

0.017

down

SCO4253

conserved hypothetical protein

5.93E-05

5.66E-03

down

SCO4256

possible hydrolytic protein

0.00772

N/A

down

None

SCO4262

hypothetical protein

0.000976

0.083

down

Predicted pI = 11.7, mwt = 12884 Da

SCO4295

Cold shock protein scoF4

0.00126

0.053

down

Predicted mwt = 7387 Da

SCO4442

hypothetical protein

0.00608

0.09*

down

Predicted mwt = 6484 Da

SCO4653

50S ribosomal protein

N/A

0.097*

down

None

SCO4661

elongation factor G

N/A

0.088*

down

None

SCO4677

possible regulatory protein

N/A

0.038*

down

SCO4703

50S ribosomal protein

N/A

0.076*

down

Predicted pI = 10.0

SCO4704

50S ribosomal protein

N/A

0.044*

down

Predicted pI = 10.6

SCO4705

50S ribosomal protein

N/A

0.087*

down

Predicted pI = 11.3

SCO4706

30S ribosomal protein

N/A

0.095*

down

Predicted pI = 10.8

SCO4707

50S ribosomal protein

N/A

0.091*

down

Predicted pI = 10.2

SCO4712

50S ribosomal protein

N/A

0.087*

down

Predicted pI = 10.2

SCO4713

50S ribosomal protein

N/A

0.076*

down

Predicted pI = 10.3

SCO4714

50S ribosomal protein

N/A

0.088*

down

Predicted pI = 9.6

SCO4716

30S ribosomal protein

N/A

0.077*

down

Predicted pI = 9.6

SCO4717

50S ribosomal protein

N/A

0.043*

down

Predicted pI = 9.8

SCO4718

50S ribosomal protein

N/A

0.074*

down

Predicted pI = 10.6

SCO4719

30S ribosomal protein

N/A

0.071*

down

Predicted pI = 10.1

SCO4994

hypothetical protein

0.0136

N/A

down

Predicted 1 transmembrane domain

SCO5013

secreted protein

0.0479

N/A

down

Secreted

SCO5073

possible oxidoreductase

4.79E-02

0*

down

SCO5074

possible dehydratase

N/A

0*

down

Predicted pI = 8.6; secreted

SCO5079

conserved hypothetical protein

N/A

0*

down

SCO5123

membrane protein

0.000415

N/A

down

Predicted pI = 8.2, mwt = 6622 Da

SCO5124

hypothetical protein

0.00512

N/A

down

Predicted pI = 7.12, mwt = 7054 Da

SCO5125

hypothetical protein

0.000788

N/A

down

None

SCO5166

putative helicase

5.12E-03

N/A

up

Predicted pI = 9.5

SCO5225

ribonucleotide-diphosphate reductase small chain

N/A

0.007*

up

Predicted 2 transmembrane domains

SCO5624

30S ribosomal protein S2

N/A

0.089*

down

None

SCO5649

unknown

N/A

0.1*

down

None

SCO6197

secreted protein

3.29E-06

0.063

down

Secreted

SCO6198

secreted protein

8.09E-03

N/A

down

Secreted

SCO6346

hypothetical protein

6.08E-03

N/A

down

None

SCO6362

Probable two-component sensor

0.00589

N/A

down

Predicted 6 transmembrane domains; pI = 10.43

SCO6637

hypothetical protein

0.000788

N/A

down

SCO6638

hypothetical protein

0.000415

N/A

down

SCO6808

possible ArsR-family regulator

0.00219

N/A

down

Predicted mwt = 13271 Da

SCO6958

putative membrane protein

0.036

N/A

up

Predicted 3 transmembrane domains; pI= 8.7; mwt = 11304 Da

SCO7510

peptidyl-prolyl cis-trans isomerase

N/A

0.01*

up

None

SCO7511

glyceraldehyde 3-phosphate dehydrogenase

N/A

0*

up

SCO7657

secreted protein

1.76E-05

0.066*

down

Secreted