Table 1 Functional classification of genes differentially expressed during commitment phase
GO biological process terms | p-value | GO biological process terms | p-value |
|---|---|---|---|
Genes up-regulated in erythroblasts | |||
heme biosynthesis | 8.3593E-09 | tRNA metabolism | 4.7686E-04 |
heme metabolism | 4.1178E-08 | nitrogen compound metabolism | 0.0011 |
pigment biosynthesis | 7.8243E-08 | cholesterol biosynthesis | 0.0021 |
porphyrin biosynthesis | 8.0158E-08 | amino acid activation | 0.0022 |
pigment metabolism | 1.8805E-07 | tRNA aminoacylation for protein translation | 0.0022 |
porphyrin metabolism | 2.5313E-07 | tRNA aminoacylation | 0.0022 |
carboxylic acid metabolism | 3.5431E-07 | electron transport | 0.0023 |
organic acid metabolism | 4.0819E-07 | amino acid and derivative metabolism | 0.0025 |
secondary metabolism | 5.8601E-07 | amine metabolism | 0.0037 |
heterocycle metabolism | 4.7133E-06 | lipid metabolism | 0.0037 |
cellular biosynthesis | 6.9372E-06 | steroid biosynthesis | 0.0041 |
cofactor metabolism | 1.0534E-05 | cholesterol metabolism | 0.0041 |
cofactor biosynthesis | 1.9914E-05 | iron ion homeostasis | 0.0042 |
generation of precursor metabolites and energy | 3.9831E-05 | sterol biosynthesis | 0.0045 |
cellular metabolism | 5.6290E-05 | mitotic cell cycle | 0.0059 |
lipid biosynthesis | 1.6546E-04 | alcohol metabolism | 0.0060 |
cellular lipid metabolism | 2.3765E-04 | sterol metabolism | 0.0061 |
amino acid metabolism | 4.3568E-04 | Â | Â |
Genes up-regulated in megakaryoblasts | |||
hemostasis | 0.0010 | positive regulation of cell proliferation | 0.0024 |
endocytosis | 0.0011 | steroid metabolism | 0.0024 |
cellular lipid metabolism | 0.0012 | lipid biosynthesis | 0.0026 |
wound healing | 0.0014 | regulation of receptor mediated endocytosis | 0.0034 |
lipid metabolism | 0.0020 | localization of cell | 0.0049 |
alcohol metabolism | 0.0020 | cell motility | 0.0049 |
regulation of body fluids | 0.0024 | cytoskeleton organization and biogenesis | 0.0081 |
transport | 0.0024 | cholesterol biosynthesis | 0.0089 |
Genes up-regulated in monoblasts | |||
response to biotic stimulus | 6.3071E-15 | antimicrobial humoral response | 3.1669E-04 |
immune response | 2.8466E-13 | detection of stimulus | 6.8750E-04 |
defense response | 7.3698E-13 | protein kinase cascade | 0.0010 |
response to pest, pathogen or parasite | 1.2074E-12 | wound healing | 0.0014 |
response to other organism | 2.4524E-12 | intracellular signaling cascade | 0.0017 |
response to external stimulus | 1.0443E-10 | positive regulation of cellular process | 0.0017 |
response to stimulus | 8.1038E-10 | endocytosis | 0.0019 |
response to wounding | 1.3630E-09 | I-kappaB kinase/NF-kappaB cascade | 0.0025 |
response to stress | 2.1560E-08 | lymphocyte activation | 0.0031 |
inflammatory response | 3.0602E-08 | blood coagulation | 0.0034 |
cell communication | 5.0323E-07 | taxis | 0.0035 |
signal transduction | 7.7480E-07 | chemotaxis | 0.0035 |
organismal physiological process | 8.0044E-07 | innate immune response | 0.0037 |
response to pathogen | 3.1842E-06 | coagulation | 0.0038 |
humoral immune response | 3.4723E-05 | locomotory behavior | 0.0044 |
detection of biotic stimulus | 4.6946E-05 | hemostasis | 0.0045 |
response to bacteria | 6.7200E-05 | carbohydrate metabolism | 0.0048 |
response to pathogenic bacteria | 9.7266E-05 | cell surface receptor linked signal transduction | 0.0059 |
immune cell activation | 1.0815E-04 | positive regulation of biological process | 0.0064 |
cell activation | 1.2116E-04 | macrophage activation | 0.0093 |
humoral defense mechanism (sensu Vertebrata) | 1.4837E-04 | regulation of body fluids | 0.0097 |
antimicrobial humoral response (sensu Vertebrata) | 2.8361E-04 | Â | Â |
Genes up-regulated in myeloblasts | |||
carboxylic acid metabolism | 2.2728E-05 | defense response | 0.0018 |
organic acid metabolism | 2.3815E-05 | response to biotic stimulus | 0.0025 |
cellular biosynthesis | 7.1605E-04 | immune response | 0.0048 |
biosynthesis | 0.0016 | positive regulation of cell proliferation | 0.0069 |