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Table 5 Identified motifs in promoters of 25 human RefSeq cardiac genes in group c

From: Inference of transcriptional regulation using gene expression data from the bovine and human genomes

Motif (Seqs; Sites)

Best hit

Score (S)

p-value (P)

CorrectedP

c1 h (20; 49)

SP1_Q2_01 (10)

0.86

4.54 × 10-1

0.48

 

SP1_Q6 (13)

0.99

6.02 × 10-1

0.60

c2 h (15; 36)

GATA4_Q3 (12)

0.96

2.40 × 10-2

0.07

c4 h (11; 30)

Pax-4* (30)

0.95

0.00

0.00

c9 h (6; 7)

PAX_Q6 (11)

0.44

3.00 × 10-3

0.03

c10 h (5; 6)

RP58_01 (12)

0.90

1.80 × 10-2

0.07

c11 h (3; 8)

TBP_Q6 (7)

0.73

1.70 × 10-2

0.07

c12 h (12; 8)

TBP_Q6 (7)

0.71

4.00 × 10-2

0.08

c14 h (8; 12)

NGFIC_01 (12)

0.89

4.00 × 10-3

0.03

c15 h (12; 17)

MAZ_Q6 (8)

0.66

2.70 × 10-2

0.07

  1. The sequences were analysed by MEME to predict common motifs. The resulting motifs were compared to the TRANSFAC and JASPAR databases for identifying known binding sites. The dissimilarity score (S) and p-value (P) for each comparison are shown. Corrected p-value for each match is based on an estimated FDR of 10%. Matches to the JASPAR database are marked by (*). Sequence logos for the matrices are given in Figure 4.
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BMC Genomics

ISSN: 1471-2164

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