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Table 2 Enriched GOTERM Cellular Component in the list of differentially expressed genes at 4 h after HAL-PDT

From: Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate

GOTERM Cellular Component (level 5)

Gene Count

%

P-Value*

Total/Down regulated gene list

mitochondrion

418/345

4.1

1.1E-17

mitochondrial envelope

124/104

1.2

2.2E-07

nuclear lumen

230/196

2.2

3.5E-07

mitochondrial membrane

113/94

1.1

1.3E-06

nucleus

2001/1390

19.5

1.3E-06

mitochondrial inner membrane

95/77

0.9

2.4E-06

mitochondrial lumen

56/50

0.5

7.7E-06

ribosome

223/200

2.2

0.000023

nucleolus

74/69

0.7

0.000035

large ribosomal subunit

41/34

0.4

0.00026

nucleoplasm

157/128

1.5

0.00062

cytosolic ribosome (sensu Eukaryota)

32/29

0.3

0.0007

mitochondrial electron transport chain

32/22

0.3

0.0007

cytosolic large ribosomal subunit (sensu Eukaryota)

23/20

0.2

0.00074

organellar ribosome

23/20

0.2

0.0018

mitochondrial ribosome

23/20

0.2

0.0018

heterogeneous nuclear ribonucleoprotein complex

15/15

0.1

0.0021

spliceosome complex

44/39

0.4

0.0039

small nucleolar ribonucleoprotein complex

21/21

0.2

0.0046

endoplasmic reticulum lumen

15/14

0.1

0.0063

proton-transporting ATP synthase complex (sensu Eukaryota)

12/9

0.1

0.011

endoplasmic reticulum

291/219

2.8

0.015

small nuclear ribonucleoprotein complex

13/13

0.1

0.017

proton-transporting two-sector ATPase complex

35/26

0.3

0.018

organellar small ribosomal subunit

12/11

0.1

0.029

endoplasmic reticulum membrane

55/47

0.5

0.035

Up-regulated gene list

integral to plasma membrane

297

6.0

1.4E-06

intercellular junction

32

0.6

0.035

nucleosome

20

0.4

0.041

chromatin

38

0.8

0.044

actin cytoskeleton

47

0.9

0.14

nucleus

752

15.2

0.16

microsome

31

0.6

0.18

cytoskeleton

175

3.5

0.22

apical junction complex

15

0.3

0.33

microtubule associated complex

24

0.5

0.37

mitochondrial electron transport chain

10

0.2

0.4

  1. *The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.