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Table 2 Enriched GOTERM Cellular Component in the list of differentially expressed genes at 4 h after HAL-PDT

From: Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate

GOTERM Cellular Component (level 5) Gene Count % P-Value*
Total/Down regulated gene list
mitochondrion 418/345 4.1 1.1E-17
mitochondrial envelope 124/104 1.2 2.2E-07
nuclear lumen 230/196 2.2 3.5E-07
mitochondrial membrane 113/94 1.1 1.3E-06
nucleus 2001/1390 19.5 1.3E-06
mitochondrial inner membrane 95/77 0.9 2.4E-06
mitochondrial lumen 56/50 0.5 7.7E-06
ribosome 223/200 2.2 0.000023
nucleolus 74/69 0.7 0.000035
large ribosomal subunit 41/34 0.4 0.00026
nucleoplasm 157/128 1.5 0.00062
cytosolic ribosome (sensu Eukaryota) 32/29 0.3 0.0007
mitochondrial electron transport chain 32/22 0.3 0.0007
cytosolic large ribosomal subunit (sensu Eukaryota) 23/20 0.2 0.00074
organellar ribosome 23/20 0.2 0.0018
mitochondrial ribosome 23/20 0.2 0.0018
heterogeneous nuclear ribonucleoprotein complex 15/15 0.1 0.0021
spliceosome complex 44/39 0.4 0.0039
small nucleolar ribonucleoprotein complex 21/21 0.2 0.0046
endoplasmic reticulum lumen 15/14 0.1 0.0063
proton-transporting ATP synthase complex (sensu Eukaryota) 12/9 0.1 0.011
endoplasmic reticulum 291/219 2.8 0.015
small nuclear ribonucleoprotein complex 13/13 0.1 0.017
proton-transporting two-sector ATPase complex 35/26 0.3 0.018
organellar small ribosomal subunit 12/11 0.1 0.029
endoplasmic reticulum membrane 55/47 0.5 0.035
Up-regulated gene list
integral to plasma membrane 297 6.0 1.4E-06
intercellular junction 32 0.6 0.035
nucleosome 20 0.4 0.041
chromatin 38 0.8 0.044
actin cytoskeleton 47 0.9 0.14
nucleus 752 15.2 0.16
microsome 31 0.6 0.18
cytoskeleton 175 3.5 0.22
apical junction complex 15 0.3 0.33
microtubule associated complex 24 0.5 0.37
mitochondrial electron transport chain 10 0.2 0.4
  1. *The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.