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Table 4 Enriched GOTERM Biological Process in the list of alternatively spliced genes

From: Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate

Up-regulated splice variants, with fold change [≥1] at 4 h

Gene Count

%

P-Value*

regulation of protein metabolism

5

5.7

0.029

cellular protein metabolism

24

27.3

0.041

phosphate metabolism

9

10.2

0.097

cytoskeleton organization and biogenesis

5

5.7

0.16

RNA metabolism

5

5.7

0.23

biopolymer modification

12

13.6

0.27

macromolecule biosynthesis

6

6.8

0.49

Down regulated splice variants, with fold change [≥1] at 4 h

cellular lipid metabolism

15

6.4

0.0094

negative regulation of cellular metabolism

8

3.4

0.035

membrane lipid metabolism

6

2.6

0.042

regulation of progression through cell cycle

13

5.5

0.044

intracellular transport

15

6.4

0.058

biopolymer modification

33

14.0

0.06

establishment of cellular localization

15

6.4

0.063

DNA metabolism

15

6.4

0.073

amino acid metabolism

8

3.4

0.073

protein catabolism

7

3.0

0.1

intracellular protein transport

9

3.8

0.1

biopolymer catabolism

7

3.0

0.13

regulation of protein kinase activity

5

2.1

0.15

carboxylic acid metabolism

11

4.7

0.15

endocytosis

5

2.1

0.17

cofactor biosynthesis

5

2.1

0.18

steroid metabolism

5

2.1

0.18

negative regulation of cell proliferation

5

2.1

0.2

lipid biosynthesis

6

2.6

0.22

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism

37

15.7

0.26

apoptosis

11

4.7

0.31

transcription

37

15.7

0.33

cellular macromolecule catabolism

7

3.0

0.36

protein complex assembly

6

2.6

0.4

protein transport

10

4.3

0.44

chromosome organization and biogenesis

6

2.6

0.44

vesicle-mediated transport

7

3.0

0.45

synaptic transmission

5

2.1

0.46

  1. *The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.