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Table 4 Enriched GOTERM Biological Process in the list of alternatively spliced genes

From: Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate

Up-regulated splice variants, with fold change [≥1] at 4 h Gene Count % P-Value*
regulation of protein metabolism 5 5.7 0.029
cellular protein metabolism 24 27.3 0.041
phosphate metabolism 9 10.2 0.097
cytoskeleton organization and biogenesis 5 5.7 0.16
RNA metabolism 5 5.7 0.23
biopolymer modification 12 13.6 0.27
macromolecule biosynthesis 6 6.8 0.49
Down regulated splice variants, with fold change [≥1] at 4 h
cellular lipid metabolism 15 6.4 0.0094
negative regulation of cellular metabolism 8 3.4 0.035
membrane lipid metabolism 6 2.6 0.042
regulation of progression through cell cycle 13 5.5 0.044
intracellular transport 15 6.4 0.058
biopolymer modification 33 14.0 0.06
establishment of cellular localization 15 6.4 0.063
DNA metabolism 15 6.4 0.073
amino acid metabolism 8 3.4 0.073
protein catabolism 7 3.0 0.1
intracellular protein transport 9 3.8 0.1
biopolymer catabolism 7 3.0 0.13
regulation of protein kinase activity 5 2.1 0.15
carboxylic acid metabolism 11 4.7 0.15
endocytosis 5 2.1 0.17
cofactor biosynthesis 5 2.1 0.18
steroid metabolism 5 2.1 0.18
negative regulation of cell proliferation 5 2.1 0.2
lipid biosynthesis 6 2.6 0.22
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 37 15.7 0.26
apoptosis 11 4.7 0.31
transcription 37 15.7 0.33
cellular macromolecule catabolism 7 3.0 0.36
protein complex assembly 6 2.6 0.4
protein transport 10 4.3 0.44
chromosome organization and biogenesis 6 2.6 0.44
vesicle-mediated transport 7 3.0 0.45
synaptic transmission 5 2.1 0.46
  1. *The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.