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Table 6 Predicted functions of down-regulated genes

From: A rapid genome-wide response to Drosophila melanogaster social interactions

Gene identifier

Gene name

Location

GO molecular function

GO biological process

Immune response

CG6639

 

36C9

chymotrypsin activity

proteolysis

y

CG4740

AttC

50A3

unknown

antibacterial humoral response

y

CG18372

AttB

51C1

unknown

antibacterial humoral response

y

CG10146

AttA

51C1

unknown

antibacterial humoral response

y

CG4757

 

86D5

carboxylesterase

unknown

y

CG15066

IM23

55C4

unknown

antibacterial humoral response

y

CG8175

Mtk

52A1

unknown

antibacterial/antifungal humoral response

y

CG1367

CecA2

99E2

unknown

antibacterial humoral response

y

CG13422

 

57A4

glucosidase

antibacterial defense response

y

CG10810

Drs

63D2

ion channel inhibitor

antibacterial/antifungal humoral response

y

CG10816

Dro

51C1

unknown

antibacterial humoral response

y

CG18563

 

36C9

trypsin activity

proteolysis

y

CG1365

CecA1

99E2

unknown

antibacterial humoral response

y

CG6687

 

88E3

serine-type endopeptidase inhibitor; ATP synthase

ATP synthesis coupled protein transport; proteolysis

y

CG18108

IM1

55C4

unknown

defense response

y

CG9989

 

98E1

unknown

unknown

n

CG5550

 

53D10

receptor binding

defense response

y

CG2217

 

99F3-4

unknown

unknown

n

CG15065

 

55C4

unknown

unknown

y

CG14745

PGRP-SC2

44E2

peptidoglycan binding

defense response

y

CG9434

Fst

85E2

unknown

response to cold

y

CG2042

 

39D1

unknown

unknown

n

CG16772

 

38A8

unknown

unknown

n

CG13947

 

21E2

unknown

unknown

n

CG18279

IM10

50A5

unknown

antibacterial humoral response

y

CG13482

 

70D5

unknown

unknown

y

CG18106

IM2

55C4

unknown

defense response

y

CG11992

Rel

85C3

transcription factor

defense response

y

CG16844

IM3

55C4

unknown

antibacterial humoral response

y

CG15231

IM4

57B3

unknown

defense response

y

CG18067

 

57A5

unknown

unknown

y

CG10332/IM18

 

59F4

unknown

defense response

y

CG10947

 

38C6

unknown

unknown

n

  1. Twenty-seven of the 33 down-regulated genes likely function in the immune response. CG15065 is closely related to IM2. Immune responsive genes are overrepresented in this data set (p = 3.163 × 10-32, Fisher's Exact Test).