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Table 3 List of the top 15 most significantly expressed genes in MCF-7 cells or in skeletal muscle as determined using the Actichip microarray

From: Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton

 

Gene name

Gene Accession number

Score (d)

Log2 expression ratio

Genes mainly expressed in skeletal muscle

Nebulette (Actin-binding Z-disk protein)

NM_006393

42.93

3.81

 

Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)

NM_003282

34.39

2.60

 

Huntingtin interacting protein 1 (HIP-I)

NM_005338

33.55

2.59

 

Myosin light chain 2a

NM_021223

32.80

3.26

 

Troponin C, skeletal muscle

NM_003279

32.21

2.45

 

Myosin light chain 2

NM_013292

29.25

3.06

 

Myosin heavy chain, skeletal muscle, perinatal

NM_002472

28.14

2.80

 

Troponin T, fast skeletal muscle isoforms

NM_006757

26.04

2.71

 

Myosin heavy chain, cardiac muscle beta isoform

NM_000257

24.94

3.12

 

Actin, alpha skeletal muscle (Alpha-actin 1)

NM_001100

24.21

3.50

 

Troponin C, slow

NM_003280

21.31

2.54

 

Nebulin

NM_004543

20.17

2.78

 

Smoothelin

NM_134269

19.50

1.32

 

Tropomyosin 1 alpha chain (Alpha-tropomyosin)

NM_000366

18.92

1.99

 

Myotilin

NM_006790

18.07

1.56

Genes mainly expressed in MCF-7 cells

Actin, cytoplasmic 2 (Gamma-actin)

NM_001614

-30.24

-2.58

 

Elongation factor 1-beta (EF-1-beta)

NM_001959

-22.14

-1.26

 

Actin binding protein anillin,

NM_018685

-20.12

-1.13

 

Keratin, type I cytoskeletal 18

NM_000224

-18.78

-2.83

 

Ankyrin 3 (ANK-3) (Ankyrin G)

NM_020987

-16.43

-2.17

 

Gamma-parvin

NM_022141

-16.30

-1.03

 

Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin)

NM_006946

-16.28

-0.84

 

Coronin 1B (Coronin 2)

NM_020441

-15.97

-0.84

 

Beta-centractin (Actin-related protein 1B) (ARP1B)

NM_005735

-15.79

-1.40

 

NB thymosin beta

NM_021992

-14.92

-1.42

 

Coronin 2A (WD-repeat protein 2) (IR10)

NM_052820

-14.39

-1.24

 

ARP2/3 complex 16 kDa subunit (P16-ARC) (Actin-related protein 2/3 complex subunit 5)

NM_005717

-13.74

-1.06

 

Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1)

NM_003257

-13.70

-1.28

 

Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1)

NM_003202

-13.60

-0.67

 

Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas))

NM_001331

-13.60

-0.77

  1. The gene list was established from our dataset through SAM analysis [64]. In SAM, the significant genes are represented on a plot by points displaced by a distance denoted as the score (d) from a line on which genes identified simply by chance are aligned. Log2 expression ratios were determined by averaging the Log2 ratios calculated from fluorescence intensities of 10 repeated hybridisations.
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BMC Genomics

ISSN: 1471-2164

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