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Table 2 Reversible gene expression upon smoking cessation related to xenobiotic metabolism and DNA adduct formation (genes in bold have not been previously associated with smoking)

From: Effect of active smoking on the human bronchial epithelium transcriptome

Tag Gene Symbol Gene Name CS Mean* FS Mean* NS Mean* P-Value (CVsF)
GGCCCAGGCC ALDH3A1 Aldehyde dehydrogenase 3 family, memberA1 4355 313 261 0.00002
TTAAAAATTC ADH7 Alcohol dehydrogenase 7 (class IV) 899 145 130 0.00002
AGGTCTGCCA*** AKR1C2 Aldo-keto reductase family 1, member C2 547 116 74 0.00002
AATGCTTTTA CYP1B1 Cytochrome P450, family 1, subfamily B, polypeptide 1 204 13 0 0.00002
TTGGAATCCA STAU2 Staufen, RNA binding protein, homolog 2 (Drosophila) 67 17 23 0.00002
TTATCAAATC NQO1 NAD(P)H dehydrogenase, quinone 1 809 202 149 0.00003
CAAATAAACC PIR Pirin (iron-binding nuclear protein) 260 47 43 0.00003
GGCCCCATTT CBR1 Carbonyl reductase 1 144 31 24 0.00003
TATTTTTGTT TXNRD1 Thioredoxin reductase 1 250 88 78 0.00006
GGTGGTGTCT GPX2 Glutathione peroxidase 2 (gastrointestinal) 384 40 46 0.00011
TATTTTTGAA DRB1 Developmentally regulated RNA-binding protein 1 204 32 22 0.00011
TGGGAGTGGG** NMNAT2 Nicotinamide nucleotide adenylyltransferase 2 175 17 9 0.00011
CAAGACCAGT GSTA2 Glutathione S-transferase A2 1436 485 528 0.00019
GCTTGAATAA AKR1B10 Aldo-keto reductase family 1, member B10 (aldose reductase) 332 10 15 0.0003
GTGCAGGGAG SPDEF SAM pointed domain containing ets transcription factor 239 64 50 0.0003
GGAGGCTTCC MECR Mitochondrial trans-2-enoyl-CoA reductase 85 26 22 0.0003
GTGATGTAAG SRXN1 Sulfiredoxin 1 homolog (S. cerevisiae) 63 14 11 0.0003
TATGCTTTAA NT5DC1 5'-nucleotidase domain containing 1 59 23 24 0.0003
GAACGCCTAA DPYSL2 Dihydropyrimidinase-like 2 1 21 23 0.0004
TTTTCTGAAA TXN Thioredoxin 698 326 212 0.00048
CTTGCATAAG CYP1A1 Cytochrome P450, family 1, subfamily A, polypeptide 1 89 2 0 0.00048
GCAAGAAGAG ALDH3A1 Aldehyde dehydrogenase 3 family, memberA1 77 10 2 0.00048
AGAACAAAAC PRDX1 Peroxiredoxin 1 1043 418 510 0.00071
AAATATTTAA SLC35A3 Solute carrier family 35, member A3 47 14 19 0.00071
CGGCTGAATT PGD Phosphogluconate dehydrogenase 252 104 80 0.00106
CTTATCAGTA BTBD7 BTB (POZ) domain containing 7 94 22 2 0.00106
AAGAGTTTTG AKR1B1 Aldo-keto reductase family 1, member B1 (aldose reductase) 25 5 6 0.00141
GCTGAGATGA** CYP4F11 Cytochrome P450, family 4, subfamily F, polypeptide 11 22 6 2 0.00141
GGCGCCTCCT TALDO1 Transaldolase 1 232 76 94 0.00152
GACACAGCAA ENTPD8 Ectonucleoside triphosphate diphosphohydrolase 8 24 3 2 0.00159
CAGTCTAAAA UCHL1 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 92 4 0 0.00197
ACATCCTAGG ALDH1A1 Aldehyde dehydrogenase 1 family, member A1 60 28 30 0.00216
TTAGAAGGAA NQO1 NAD(P)H dehydrogenase, quinone 1 41 14 9 0.00216
AGGTCTACCA AKR1C2 Aldo-keto reductase family 1, member C2 270 32 8 0.00292
ATTAGGCCTG TXNRD1 Thioredoxin reductase 1 51 19 17 0.00297
GAGAGCTTTG AKR1C3 Aldo-keto reductase family 1, member C3 149 21 22 0.00298
TACGCTTGGT CYB5R1 Cytochrome b5 reductase 1 68 32 30 0.00298
CACTGCCTTG FTH1 Ferritin, heavy polypeptide 1 59 23 17 0.00298
CTGCTGCACT GSR Glutathione reductase 126 54 50 0.0041
GGCAAAATTA SLC35A3 Solute carrier family 35, member A3 73 32 35 0.0041
ACCTTGGGGT NQO1 NAD(P)H dehydrogenase, quinone 1 73 19 6 0.0041
AATGTTCAGG COQ6 Coenzyme Q6 homolog, monooxygenase (yeast) 29 12 4 0.00708
CACTGACCAG NOD27 Nucleotide-binding oligomerization domains 27 31 10 0 0.00927
CTCGGAGGCC SEPX1 Selenoprotein X, 1 71 32 28 0.00956
CTCCAAAAAA CPSF2 Cleavage and polyadenylation specific factor 2, 100 kDa 118 44 14 0.02013
AATGGAAACT GCLM Glutamate-cysteine ligase, modifier subunit 34 16 9 0.03186
  1. * Mean in tags per million (TPM)
  2. ** Changed mapping with TAGMapper [56]
  3. ***Tag maps with equal reliability to AKR1C1