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Table 2 Maximum NPLOD score values for linkage families in the candidate regions

From: Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies

CHR

FAMILY

From

To

SNP-GWS

p value

SNP-GWS + STRs

p value

  

SNP

cM

SNP

cM

    

2

3395

rs714513

50.2

rs1167465

61.6

    

3

154*

rs4796

54.5

rs2030395

68.5

4.07

0.00001

1.90

0.03

3

2191*

rs893367

67.5

rs1392702

70.7

2.06

0.02

0.17

0.4

3

3395*

rs1127732

56

rs1024008

94.5

2.38

0.01

0.64

0.3

4

8

rs936232

37.1

rs894905

60.5

2.22

0.01

2.23

0.01

4

14*

rs12142

49

rs1560605

74.1

3.03

0.001

0.27

0.4

4

2191

rs1456087

39.7

rs1560605

74.1

5.00

0.00001

4.98

0.00001

7

14*

rs917424

88.3

rs875588

164.2

3.42

0.0005

2.84

0.003

7

3386

rs2009526

76.6

rs1990790

134.2

1.89

0.03

1.84

0.03

7

3568

rs917089

98.3

rs322812

131.3

2.33

0.01

2.33

0.01

11

153

rs1675090

66.6

rs586699

92.3

11.40

0.000001

11.47

0.000001

14

153

rs2027338

34.2

rs923908

44

10.50

0.000001

11.53

0.000001

  1. Two different sets of markers are considered: a) SNP-GWS, b) SNP-GWS plus STR fine mapping. *Families ruled out after STR fine mapping.