Figure 1
From: Yeast genomic expression patterns in response to low-shear modeled microgravity
Gene expression response to low-shear modeled microgravity. Two-dimensional hierarchical cluster heat map analysis of the microarray transcriptional profile of gene response to low-shear modeled microgravity (LSMMG) in S. cerevisiae wild-type diploid cells (BY4743) grown in HARVs (experimental group) for 5 generations (3E5, 4E5, 5E5) or 25 generations (3E25, 4E25, 5E25) versus the control group grown in HARVs for 5 generations (1C5, 2C5, 3C5, 4C5) or 25 generations (1C25, 2C25). The analysis was performed on 1372 statistically significant genes (from the filtered list of 3850 genes) with a fold change of at least 2 in one of three comparisons as described in Methods. Levels of expression are indicated on a color scale where red represents the up-regulated genes and green, the down-regulated genes. Similarities or differences in the experimental versus control gene expression patterns are represented in the horizontal dendrogram. The vertical dendrogram shows similarities in expression patterns between cultures exposed to LSMMG versus control cultures.