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Table 1 Direction and fold change of genes that establish cell polarity and bipolar budding in yeast cultured under simulated microgravity.

From: Yeast genomic expression patterns in response to low-shear modeled microgravity

Gene Genbank ID Fold Change 5 generations v. ctrl Fold Change 25 generations v. ctrl Description
Genes in the Purevdorj-Gage study [13]
RAX1 YCR301W 5.3 ↓ 5.1 ↓ bipolar budding
RAX2 YLR084C 3.2 ↓ 3.4 ↓ bipolar budding
DSE1 YER124C 8.6 ↓ 6.0 ↓ cell separation
DSE2 YHR143W 3.1 ↓ 3.1 ↓ cell separation
BUD5 YCR038C 1.7 ↑ 1.6 ↑ polarity
BUD25 YER014C-A 1.6 ↑ 1.7 ↑ bud site selection
EGT2 YNL327W 7.7 ↓ 6.1 ↓ cell separation
Bipolar budding pattern genes identified in Ni and Snyder study [19]
SLG1 YOR008C 2.2 ↑ 1.6 ↑ cell wall integrity, stress response
VMA5 YKL080W 2.1 ↓ 1.5 ↓ transport
PRS3 YHL011C 2.2 ↓ 2.0 ↓ regulation of cell size
BUD21 YOR078W 2.3 ↓ 2.6 ↓ processing
SUR4 YLR372W 2.4 ↓ 2.5 ↓ lipid metabolism
RSR1 YGR152C 2.5 ↓ 2.0 ↓ bud site selection, cell polarity
RSP18B YML026C 2.6 ↓ 3.1 ↓ ribosomal protein
RPL22A YLR061W 3.8 ↓ 4.4 ↓ ribosomal protein
FEN1 YCR034W 4.1 ↓ 3.2 ↓ lipid metabolism
NSR1 YGR159C 5.6 ↓ 7.5 ↓ nuclear protein
GAS1 YMR307W 1.8 ↓ 2.0 ↓ cell wall
BUD22 YMR014W 1.9 ↓ 2.0 ↓ bud site selection
BUD23 YCR047C 1.8 ↓ 2.4 ↓ bud site selection
STO1 YLR287C 2.1 ↓ 1.7 ↓ protein biosynthesis
--- YLR287C 2.5 ↓ 2.4 ↓ hypothetical ORF
MIPS functional category: budding and cell polarity
ERV15 YBR210W 1.8 ↑ 1.8 ↑ Axial bud site selection
BUD5 YCR038C 1.7 ↑ 1.6 ↑ bud site selection
TWF1 YGR080W 1.5 ↑ 1.6 ↑ bipolar bud site selection
BUD13 YGL174W 1.4↑ 1.4 ↑ bud site selection
BUD20 YLR074C 1.2 ↑ 1.1 ↑ bud site selection
MUB1 YMR100W 1.1 ↑ 1.2 ↑ regulation of cell budding
BUD27 YFL023W 1.1 ↑ 1.2 ↑ bud site selection
AXL1 YPR122W 1.1 ↑ 1.1 ↑ bud site selection
THP1 YOL072W 1.1 ↑ 1.2 ↑ bud site selection
LAS1 YKR063C 1.1 ↑ 1.2 ↑ budding cell bud growth
STE20 YHL007C 1.0 ↓ 1.0 ↓ bud site selection
BUD16 YEL029C 1.1 ↓ 1.0 ↓ bud site selection
BUD7 YOR299W 1.2 ↓ 1.1 ↑ bud site selection
BUD2 YKL092C 1.2 ↓ 1.1 ↓ bud site selection
BUD8 YLR353W 1.2 ↓ 1.3 ↓ bud site selection
BUD32 YGR262C 1.2 ↓ 1.3 ↓ bud site selection
BUD17 YNR027W 1.2 ↓ 1.0 ↓ bud site selection
RRP14 YKL082C 1.3 ↑ 1.4 ↓ cell polarity
BUD3 YCL014W 1.3 ↓ 1.4 ↓ bud site selection
BUD31 YCR063W 1.4 ↓ 1.3 ↓ bud site selection
BUD6 YLR319C 1.4 ↓ 1.4 ↓ bud site selection
AXL2 YIL140W 1.4 ↓ 1.4 ↓ bud site selection
HKR1 YDR420W 1.5 ↓ 1.7 ↓ bud site selection
BUD9 YGR041W 1.6 ↓ 1.9 ↓ bud site selection
TOS2 YGR221C 1.6 ↓ 1.7 ↓ budding cell bud growth
BUD23 YCR047C 1.8 ↓ 2.4 ↓ bud site selection
BUD22 YMR014W 1.9 ↓ 2.0 ↓ bud site selection
RSR1 YGR152C 2.5 ↓ 2.0 ↓ bud site selection
BUD4 YJR092W 2.7 ↓ 2.0 ↓ bud site selection
RAX2 YLR084C 3.2 ↓ 3.2 ↓ bud site selection
RAX1 YOR301W 5.3 ↓ 5.1 ↓ bud site selection