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Table 3 Characterized and predicted members of the three different glycerate kinase classes

From: Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes

Glycerate kinase class Organism Physiological function; Pathway Reaction product Literature
GK class II (MOFRL family) Archaea    
  Thermoproteustenax Glucose degradation via sugar acids (gluconate); Branched ED pathway 2-PG This manuscript, [30,32]
  Thermoplsma acidophilum    
  Facultative Methylotrophs, Methylobacterium extorquens Hyphomicrobium methylovorum Growth on C1-compounds (e.g. methane, methanol) and conversion in C3-compounds via hydroxypyruvate; Assimilatory serine pathway 2-PG [33,44-47]
  Pseudomonas sp. Growth on C1 and C2-compounds (e.g. methanol, oxalate, glycolate); Serine pathway & glyoxylate metabolism1 -  
  Agrobacterium vitis (two plasmid-encoded genes, glycerate kinase instead of hydroxypyruvate reductase activity predicted) Tartrate utilization, shares common reactions with the serine pathway; Tartrate utilization pathway 2-PG [48,49]
  Rat liver, rat kidney cortex Gluconeogenesis from serine, fructose metabolism 2-PG [51-53]
GK class I Bacteria    
  Escherichia coli (K12) GK-1 Allantoin assimilation (purine degradation); Glycerate pathway 3-PG [55]
  Escherichia coli (K12) GK-2 Sugar acid degradation; Glucarate/galactarate utilization pathway 2-PG [56]
  Pseudomonas sp. Growth on sugar or sugar acids 1 -  
  Flavobacterium strains Growth on ethylene glycol; Glycerate pathway 2-PG [57]
GK class III Eukarya    
  Plant, Arabidopsis thaliana Photorespiration; C2-cycle 3-PG [31]
  Fungi, Neurospora crassa Growth on glycerol; Oxidative glycerol metabolism 3-PG [58]
  1. 1the function of the class I and class II (MOFRL family) glycerate kinase for P. fluorescens and P. putida is predicted from genome context analysis (see text, Fig. 8); the formed reaction product is not known (-).