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Table 3 Characterized and predicted members of the three different glycerate kinase classes

From: Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes

Glycerate kinase class

Organism

Physiological function; Pathway

Reaction product

Literature

GK class II (MOFRL family)

Archaea

   
 

Thermoproteustenax

Glucose degradation via sugar acids (gluconate); Branched ED pathway

2-PG

This manuscript, [30,32]

 

Picrophilustorridus

   
 

Thermoplsma acidophilum

   
 

Bacteria

   
 

Facultative Methylotrophs, Methylobacterium extorquens Hyphomicrobium methylovorum

Growth on C1-compounds (e.g. methane, methanol) and conversion in C3-compounds via hydroxypyruvate; Assimilatory serine pathway

2-PG

[33,44-47]

 

Pseudomonas sp.

Growth on C1 and C2-compounds (e.g. methanol, oxalate, glycolate); Serine pathway & glyoxylate metabolism1

-

 
 

Agrobacterium vitis (two plasmid-encoded genes, glycerate kinase instead of hydroxypyruvate reductase activity predicted)

Tartrate utilization, shares common reactions with the serine pathway; Tartrate utilization pathway

2-PG

[48,49]

 

Eukarya

   
 

Rat liver, rat kidney cortex

Gluconeogenesis from serine, fructose metabolism

2-PG

[51-53]

GK class I

Bacteria

   
 

Escherichia coli (K12) GK-1

Allantoin assimilation (purine degradation); Glycerate pathway

3-PG

[55]

 

Escherichia coli (K12) GK-2

Sugar acid degradation; Glucarate/galactarate utilization pathway

2-PG

[56]

 

Pseudomonas sp.

Growth on sugar or sugar acids 1

-

 
 

Flavobacterium strains

Growth on ethylene glycol; Glycerate pathway

2-PG

[57]

GK class III

Eukarya

   
 

Plant, Arabidopsis thaliana

Photorespiration; C2-cycle

3-PG

[31]

 

Fungi, Neurospora crassa

Growth on glycerol; Oxidative glycerol metabolism

3-PG

[58]

  1. 1the function of the class I and class II (MOFRL family) glycerate kinase for P. fluorescens and P. putida is predicted from genome context analysis (see text, Fig. 8); the formed reaction product is not known (-).
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BMC Genomics

ISSN: 1471-2164

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