Figure 5

Meta-analysis of human multiple myeloma samples with mouse plasmacytomas. A total of 122 samples, comprised of 74 human samples and 48 mouse samples, were used for this meta-analysis. Human samples had previously classified into 4 different stages of multiple myeloma (MM1, MM2, MM3 and MM4, generally reflecting increasing severity or stage of disease [18]), and mouse samples were composed of 5 different PCT groups, ABPC and ABLMYCPC, "two accelerated subgroups [PCT-1 and -2] (Table 1)", and "TEPC, KiPC and IL6PC, the slower appearing subgroups [PCTs 4 – 6] (Table 1)". The stage of myeloma and group of plasma cell tumors to which each sample belongs is indicated by the color of the rows of boxes beneath sample names, with a color key beneath the heat map. The human and mouse data were normalized and standardized separately and then combined for analysis [40,41]. The genes for cluster analysis were selected by one-way ANOVA analysis (2266 genes, p-value < 0.001) of mouse PCTs, and 634 orthologs from these 2266 genes, present both in human and mouse array platforms were used for cluster analysis.