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Table 2 Functional classification and numbers of genes that were found differentially expressed in the femAB+ backcross BB1305 compared to the corresponding wild type BB903 as determined by microarray analysis

From: Living with an imperfect cell wall: compensation of femAB inactivation in Staphylococcus aureus

Functiona Number of ORFs Overrepresentationb
  Chip Down Up   p -value
Cell wall 63 2 0   
Membrane bioenergetics (electron transport chain and ATP synthase) 58 1 2   
Transport/binding proteins and lipoproteins 254 16 11 down < 0.001
Protein secretion 12 0 0   
Sensors (signal transduction) 19 0 0   
Cell division, germination, sporulation, and transformation/competence 34 0 0   
DNA modification, repair, recombination, replication, packaging, and segregation 80 0 3   
Protein folding and modification 35 1 1   
Protein synthesis 85 6 0 down 0.015
RNA modification 20 0 0   
RNA synthesis 132 3 8   
Metabolism of lipids 50 4 3 down 0.030
Metabolism of amino acids and related molecules 143 7 10 up 0.029
Metabolism of carbohydrates and related molecules 134 2 10 up 0.023
Metabolism of coenzymes and prosthetic groups 70 0 1   
Metabolism of nucleotides and nucleic acids 74 5 3 down 0.030
Metabolism of phosphate and sulfur 8 0 0   
Adaptation to atypical conditions 44 0 1   
Pathogenic factors (toxins and colonization factors) 97 1 9 up 0.006
Phage-related functions 43 0 7 up 0.001
Detoxification, transposon and IS, miscellaneous 66 1 2   
Similar to unknown proteins, no similarity 811 7 10   
Total ORFs 2332 56 81   
  1. aThe cellular main roles are in accordance with the annotation on the DOGAN website [73].
  2. bOverrepresented functions either among the down- or the upregulated genes are printed in bold and the respective p- values as determined by Fisher's exact test are given.