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Table 3 Top scoring reporter metabolites (p- values < 0.05)

From: Living with an imperfect cell wall: compensation of femAB inactivation in Staphylococcus aureus

Metabolisma Metabolite Number of neighbours Z-score p-value
A, E, N Carbamoyl phosphate 5 4.341 < 0.001
N N-Carbamoyl-L-aspartate 2 2.878 0.002
A, E, N Carbamate 2 2.772 0.003
Co, N Uracil 5 2.626 0.004
A L-Citrulline 3 2.484 0.006
A 4-Imidazolone-5-propanoate 2 2.480 0.007
Co, N Uracil (extracellular) 1 2.210 0.014
N Orotidine-5-phosphate 2 2.182 0.015
C Melibiose (extracellular) 1 2.092 0.018
C Raffinose (extracellular) 1 2.092 0.018
A N-Formimino-L-glutamate 2 2.087 0.018
L Trihexadecanoylglycerol 1 2.075 0.019
A L-Arginine (extracellular) 1 2.075 0.019
A L-Ornithine (extracellular) 1 2.075 0.019
L Phosphatidylethanolamine 2 2.047 0.020
L Phosphatidylcholine 2 2.047 0.020
L Choline phosphate 2 2.047 0.020
L Ethanolamine phosphate 2 2.047 0.020
A 3-Methyl-2-oxopentanoate 3 1.980 0.024
Co Nicotinate 2 1.979 0.024
C Melibiose 3 1.958 0.025
A, C, L Glycerol (extracellular) 1 1.949 0.026
N (S)-Dihydroorotate 2 1.937 0.026
C, L 1,2-Dihexadecanoyl-sn-glycerol 7 1.924 0.027
C N-Acetylneuraminate 1 1.907 0.028
C Itaconate 1 1.884 0.030
C Itaconyl-CoA 1 1.884 0.030
C Raffinose 2 1.870 0.031
A, C, N D-Ribose 2 1.860 0.031
A, C, L Glycerol 4 1.804 0.036
C, Co, N Deoxyribose 1 1.768 0.038
A 2-Aminoacrylate 1 1.746 0.040
A, N GDP 6 1.659 0.049
N Orotate 2 1.659 0.049
L (R)-5-Diphosphomevalonate 2 1.650 0.049
  1. aA, amino acid metabolism; C, carbohydrate metabolism; Co, metabolism of cofactors and vitamins; E, energy metabolism; L, lipid metabolism; N, nucleotide metabolism