Table 3 Homology relationships between the kinomes of S. cerevisiae, S. pombe and E. cuniculi

AKT

YPK1, YPK2

SPCC24B10.07 (gad8)

Viable (Sc, Sp)

AKT

SCH9

SPAC1B9.02c (sck1), SPAC22E12.14c (sck2)

Viable (Sc, Sp)

AUR

IPL1

SPCC320.13c (ark1)

CAD25568.1

Lethal (Sc, Sp)

BUB

BUB1

SPCC1322.12c (bub1)

Viable (Sc, Sp)

NDR

RIM15

SPAPB18E9.02c (ppk18), SPCC1450.11c (cek1)

Viable (Sc, Sp)

NDR

CBK1

SPAC821.12 (orb6)

CAD25005.1

Lethal (Sc, Sp)

NDR

DBF2, DBF20

SPCC417.06c (ppk35), SPAC24B11.11c (sid2)

Lethal (sid2)

PDK1

PKH1, PKH2

SPCC576.15c (ksg1)

Lethal (ksg1)

PDK1

YDR466W (PKH3)

SPBC1778.10c (ppk21)

Viable (Sc, Sp)

PKA

TPK1, TPK2, TPK3

SPBC106.10 (pka1)

CAD25584.1

Viable (Sc, Sp)

PKC

PKC1

SPAC17G8.14c (pck1), SPBC12D12.04c (pck2)

Lethal (PKC1)

RSK

KIN82

SPBC1861.09 (ppk22)

Viable (Sc, Sp)

RSK

YNR047W

SPAC4G8.05 (ppk14)

Viable (Sc, Sp)

RSK

YBR028C

SPCC4G3.08 (psk1)

Viable (Sc, Sp)

AGC unpaired

AGC unpaired

AGC unpaired

YKL171W

SPBC725.06c (ppk31)

CAD25776.1

SPCC162.10 (cmk2)

CAMK family

Sub-family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

CAMK1

CMK1, CMK2

SPACUNK12.02c (cmk1)

Viable (Sc, Sp)

CAMK1

RCK1, RCK2

SPAC23A1.06c (cmk2), SPCC1322.08 (srk1)

Viable (Sc, Sp)

CAMKK

TOS3, PAK1

SPCC297.03 (ssp1), SPCC1919.01 (ppk34)

Viable (Sc, Sp)

CAMKL

CHK1

SPCC1259.13 (chk1)

CAD26208.1

Viable (Sc, Sp)

CAMKL

KIN1, KIN2

SPBC4F6.06 (kin1), SPBC32C12.03c (ppk25)

CAD26242.1, CAD26452.1

Viable (Sc, Sp)

CAMKL

KIN4, YPL141C

SPAC110.01 (ppk1)

Viable (Sc, Sp)

CAMKL

YPL150W

SPAC890.03 (ppk16)

Viable (Sc, Sp)

CAMKL

FUN31, YOL045W

SPAC1805.01c (ppk6)

Viable (Sc, Sp)

CAMKL

SNF1

SPCC74.03c (ssp2), SPAC23H4.02 (ppk9)

Viable (Sc, Sp)

CAMKL

KCC4, GIN4, HSL1

SPAC644.06c (cdr1), SPAC57A10.02 (cdr2)

Viable (Sc, Sp)

CAMK-Unique

MEK1

SPAC14C4.03 (mek1)

Viable (Sc, Sp)

CAMK-Unique

PRR1

SPBC337.04 (ppk27)

Viable (Sc, Sp)

HAL

SAT4

SPAC29A4.16 (ppk10)

Viable (Sc, Sp)

HAL

YOR267C, YDL025C

SPCC1020.10 (oca2)

Viable (Sc, Sp)

RAD53

RAD53

SPCC18B5.11c (cds1)

Lethal (RAD53)

RAN

KSP1

SPBC16E9.13 (ppk20)

Viable (Sc, Sp)

ULK

APG1

SPCC63.08c (ppk36)

Viable (Sc, Sp)

CAMK unpaired

CAMK unpaired

CAMK unpaired

(PTK1, PTK2)

SPAC22G7.08 (ppk8)

CAD26060.1

(HAL5, KKQ8)

(SPCC70.05c (ppk37, Lethal), SPBC21.07c (ppk24))

CAD25086.1

DUN1

SPBC19C2.05

YMR291W

SPAC15A10.13

(NPR1, PRR2)

SPBP23A10.10

IKS1

YGR052W

ISR1

CK1 family

Sub-family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

CK1

YCK1

SPAC1805.05 (cki3)

CK1

YCK2

SPBC1347.06c (cki1)

CK1

YCK3

SPBP35G2.05c (cki2)

CK1

HRR25

SPBC3H7.15 (hhp1)

CAD26235.1

Lethal (HRR25)

SPAC23C4.12 (hhp2)

CAD26108.1

CMGC family

Sub-family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

CDC7

CDC7

SPBC776.12c (hsk1), SPBC21C3.18 (spo4)

CAD26498.1, CAD25731.1

Lethal (CDC7, hsk1)

CDK

KIN28

SPBC19F8.07 (crk1)

CAD25174.1

Lethal (KIN28, crk1)

CDK

CDC28

SPBC11B10.09 (cdc2)

CAD26495.1

Lethal (CDC28, cdc2)

CDK

CTK1

SPAC2F3.15 (lsk1)

CAD26006.1

Viable (Sc, Sp)

CDK

CAK1

SPAC1D4.06c (csk1)

Lethal (CAK1)

CDK

SGV1

SPBC32H8.10 (cdk9)

Lethal (SGV1, cdk9)

CDK

PHO85

SPCC16C4.11 (pef1)

Viable (Sc, Sp)

CDK

SSN3

SPAC23H4.17c (srb10)

Viable (Sc, Sp)

CK2

CKA1, CKA2

SPAC23C11.11 (cka1)

CAD26671.1

Lethal (cka1)

CLK

KNS1

SPAC1D4.11c (lkh1)

Viable (Sc, Sp)

DYRK

YAK1

SPAC823.03 (ppk15)

CAD25928.1

Viable (Sc, Sp)

GSK

RIM11, MRK1

SPBC8D2.01 (gsk31), SPAC1687.15 (gsk3)

Viable (Sc, Sp)

MAPK

FUS3, KSS1

SPAC31G5.09c (spk1)

Viable (Sc, Sp)

MAPK

HOG1

SPAC24B11.06c (sty1)

Viable (Sc, Sp)

MAPK

SLT2, YKL161C

SPBC119.08 (pmk1)

Viable (Sc, Sp)

RCK

IME2

SPAC3C7.06c (pit1), SPBC8D2.19 (mde3)

Viable (Sc, Sp)

SRPK

SKY1

SPBC530.14c (dsk1)

Viable (Sc, Sp)

TTK

MPS1

SPBC106.01 (mph1)

CAD25082.1

Lethal (MPS1)

CMGC unpaired

CMGC unpaired

CMGC unpaired

SMK1

SPAC16C9.07 (ppk5), SPAC2F7.03c (pom1)

CAD25660.1

(MCK1, YOL128C)

SPCC777.14 (prp4, Lethal)

(CAD26039.1, CAD26483.1)

SPBC336.14C

SPBC18H10.15 (ppk23)

CAD26328.1

STE family

Sub-family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

STE7

PBS2

SPBC409.07c (wis1)

(none)

Viable (Sc, Sp)

STE7

MKK1, MKK2

SPBC543.07 (pek1)

Viable (Sc, Sp)

STE7

STE7

SPAC1D4.13 (byr1)

Viable (Sc, Sp)

STE20

STE20

SPBC1604.14c (shk1)

Lethal (shk1)

STE20

CLA4, SKM1

SPAC1F5.09c (shk2)

Viable (Sc, Sp)

STE20

SPS1

SPAC2C4.14c (ppk11), SPAC9G1.09 (sid1)

Lethal (sid1)

STE20

CDC15

SPBC21.06c (cdc7)

Lethal (CDC15, cdc7)

STE20

KIC1

SPBC17F3.02 (nak1)

Lethal (KIC1, nak1)

STE11

SSK2, SSK22

SPAC1006.09 (win1), SPAC9G1.02 (wis4)

Viable (Sc, Sp)

STE11

STE11

SPBC1D7.05 (byr2)

Viable (Sc, Sp)

STE11

BCK1

SPAC1F3.02c (mkh1)

Viable (Sc, Sp)

Other group

Sub-family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

Bud32

BUD32

SPAP27G11.07c ^$$

CAD25400.1

Viable (BUD32)

GCN2

GCN2

SPAC20G4.03c (hri1)

Viable (Sc, Sp)

IRE

IRE1

SPAC167.01 (ppk4)

Viable (Sc, Sp)

NAK

YPL236C

SPAC3H1.13 (ppk13)

Viable (Sc, Sp)

NAK

AKL1, PRK1, ARK1

SPCP1E11.02 (ppk38), SPBC6B1.02 (ppk30), SPBC557.04 (ppk29)

Viable (Sc, Sp)

NEK

KIN3

SPAC19E9.02 (fin1)

Viable (Sc, Sp)

PLK

CDC5

SPAC23C11.16 (plo1)

CAD24933.1

Lethal (CDC5, plo1)

VPS15

VPS15

SPBC119.07 (ppk19)

Viable (Sc, Sp)

WEE

SWE1

SPCC18B5.03 (wee1), SPBC660.14 (mik1)

CAD26466.1

Viable (Sc, Sp)

Other unpaired

Other unpaired

Other unpaired

SCY1

SPBC15C4.02 ^$$

CAD26209.1

ELM1

SPAC12B10.14c (ppk2)

CAD26233.1

SPAC23C4.03 ^$$

SPAC222.07c (hri2)

SPBC36B7.09 (ppk28)

TKL family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

(none)

(none)

CAD26582.1

Unknown

PIKK family

S. cerevisiae

S. pombe

E. cuniculi

Deletion mutant

MEC1

SPBC216.05

TEL1

SPCC23B6.03c *

CAD25142.1, CAD25955.1

TOR1

SPBC216.07c

TOR2

SPBC30D10.10c

TRA1

SPAC1F5.11c

RIO family

S. cerevisiae

S. pombe

E. cuniculi

RIO1

SPAC10F6.10

RIO2

SPBC1703.05

CAD26627.1

PDHK family

S. cerevisiae

S. pombe

E. cuniculi

YGL059W

(none)

YIL042C

SPAC644.11c