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Table 2 The 20 most abundant conserved motifs found with Pfam
| Pfam Motif Description | Pfam Motif | N°a | Molecular Function b |
|---|---|---|---|
| Leucine Rich Repeat | PF00560.19 | 457 | protein-protein interaction |
| WD domain, G-beta repeat | PF00400.18 | 341 | protein-protein interaction |
| PPR repeat | PF01535.9 | 218 | RNA binding |
| RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | PF00076.10 | 190 | nucleic acid binding(GO:0003676)c |
| Protein kinase domain | PF00069.13 | 156 | protein kinase activity (GO:0004672)c ATP binding (GO:0005524)c |
| Ankyrin repeat | PF00023.16 | 149 | protein-protein interaction |
| EF hand | PF00036.18 | 111 | calcium ion binding (GO:0005509)c |
| Mitochondrial carrier protein | PF00153.13 | 97 | binding (GO:0005488)c |
| Myb-like DNA-binding domain | PF00249.17 | 87 | DNA binding (GO:0003677)c |
| F-box domain | PF00646.19 | 79 | protein-protein interaction |
| Tetratricopeptide repeat | PF00515.14 | 77 | protein-protein interaction |
| Armadillo/beta-catenin-like repeat | PF00514.10 | 77 | protein-protein interaction |
| Zinc finger, C3HC4 type (RING finger) | PF00097.11 | 74 | ubiquitin-protein ligase (GO:0004842)c zinc ion binding (GO:0008270)c |
| Zinc knuckle | PF00098.10 | 67 | nucleic acid binding(GO:0003676)c |
| Zinc finger C-x8-C-x5-C-x3-H type | PF00642.13 | 67 | nucleic acid binding(GO:0003676) |
| AP2 domain | PF00847.9 | 58 | transcription factor (GO:0003700)c |
| XYPPX repeat | PF02162.6 | 55 | unknown |
| Kelch motif | PF01344.13 | 49 | unknown |
| Ubiquitin family | PF00240.12 | 45 | protein modification (GO:0006464)c |
| IQ calmodulin-binding motif | PF00612.14 | 43 | calmodulin binding |
