Table 2 The 20 most abundant conserved motifs found with Pfam
Pfam Motif Description | Pfam Motif | N°a | Molecular Function b |
|---|---|---|---|
Leucine Rich Repeat | PF00560.19 | 457 | protein-protein interaction |
WD domain, G-beta repeat | PF00400.18 | 341 | protein-protein interaction |
PPR repeat | PF01535.9 | 218 | RNA binding |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | PF00076.10 | 190 | nucleic acid binding(GO:0003676)c |
Protein kinase domain | PF00069.13 | 156 | protein kinase activity (GO:0004672)c ATP binding (GO:0005524)c |
Ankyrin repeat | PF00023.16 | 149 | protein-protein interaction |
EF hand | PF00036.18 | 111 | calcium ion binding (GO:0005509)c |
Mitochondrial carrier protein | PF00153.13 | 97 | binding (GO:0005488)c |
Myb-like DNA-binding domain | PF00249.17 | 87 | DNA binding (GO:0003677)c |
F-box domain | PF00646.19 | 79 | protein-protein interaction |
Tetratricopeptide repeat | PF00515.14 | 77 | protein-protein interaction |
Armadillo/beta-catenin-like repeat | PF00514.10 | 77 | protein-protein interaction |
Zinc finger, C3HC4 type (RING finger) | PF00097.11 | 74 | ubiquitin-protein ligase (GO:0004842)c zinc ion binding (GO:0008270)c |
Zinc knuckle | PF00098.10 | 67 | nucleic acid binding(GO:0003676)c |
Zinc finger C-x8-C-x5-C-x3-H type | PF00642.13 | 67 | nucleic acid binding(GO:0003676) |
AP2 domain | PF00847.9 | 58 | transcription factor (GO:0003700)c |
XYPPX repeat | PF02162.6 | 55 | unknown |
Kelch motif | PF01344.13 | 49 | unknown |
Ubiquitin family | PF00240.12 | 45 | protein modification (GO:0006464)c |
IQ calmodulin-binding motif | PF00612.14 | 43 | calmodulin binding |