Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes

Table 2 Equine OAS1 single nucleotide polymorphisms and microsatellites

Region	AccessionDQ536887	Alleles	Residue	Amino Acid Type	Frequency	Polymorphism
-	3640	C	-	-	0.25	Transition
		T			0.75
-	3687	G	-	-	0.65	Transversion
		T			0.35
-	3718	A	-	-	0.65	Transition
		G			0.35
-	3724	C	-	-	0.65	Transition
		T			0.35
-	3825	C	-	-	0.35	Transition
		T			0.65
-	3830	A	-	-	0.85	Transversion
		T			0.15
-	3973	C	-	-	0.65	Transition
		T			0.35
-	4032–4063	-	-	-	-	GT repeat
-	4234	C	-	-	0.65	Transition
		T			0.35
-	4333	C	-	-	0.35	Transition
		T			0.65
-	4455	C	-	-	0.08	Transversion
		G			0.92
-	4487	C	-	-	0.88	Transition
		T			0.12
-	4501	C	-	-	0.65	Transition
		T			0.35
-	4531	A	-	-	0.08	Transition
		G			0.92
5' UTR	4598	C	-	-	0.65	Transversion
		G			0.35
5' UTR	4625	A	-	-	0.35	Transversion
		C			0.65
Exon 1	4690	A	18Tyr	Uncharged Polar	0.85	Transition
		G	18Cys	Uncharged Polar	0.15
Exon 1	4783	C	49Ala	Nonpolar	0.35	Transition
		T	49Val	Nonpolar	0.65
Intron 1	5609	C	-	-	0.67	Transition
		T			0.33
Exon 2	5701	C	77Leu	Nonpolar	0.64	Transition
		T	77Leu		0.36
Exon 2	5743	C	91Phe	Nonpolar	0.33	Transition
		T	91Phe		0.67
Exon 2	5765	A	99Lys	Basic Polar	0.65	Transition
		G	99Glu	Acidic Polar	0.35
Exon 2	5776	A	102Arg	Basic Polar	0.38	Transition
		G	102Arg		0.62
Exon 2	5786	A	106Lys	Basic Polar	0.38	Transition
		G	106Glu	Acidic Polar	0.62
Exon 2	5920	G	150Pro	Nonpolar	0.08	Transversion
		T	150Pro		0.92
Exon 3	9374	C	209Arg	Basic Polar	0.85	Transition
		T	209Cys	Uncharged Polar	0.15
Exon 4	12714	C	264Asn	Uncharged Polar	0.59	Transversion
		G	264Lys	Basic Polar	0.41
Intron 4	12810	C	-	-	0.64	Transition
		T			0.36
Intron 4	12853	A	-	-	0.55	Transition
		G			0.45
Intron 5	13628	A	-	-	0.55	Transversion
		T			0.45
Intron 5	13649	C	-	-	0.46	Transversion
		G			0.54
Exon 6	15320	C	370Arg	Basic Polar	0.75	Transition
		T	370Trp	Nonpolar	0.25
3' UTR	15410	G	-	-	0.62	Transversion
		T			0.38
3' UTR	15537	G	-	-	0.19	Transversion
		T			0.81
-	15798–15855	-	-	-	-	GT repeat

SNPs and microsatellites identified from sequencing the OAS1 proximal promoter and exons from 13 equine individuals and CHORI BAC 100I10. Positions are identified from the genomic consensus sequence submitted to GenBank [GenBank: DQ536887].

ISSN: 1471-2164