A Marfan syndrome gene expression phenotype in cultured skin fibroblasts

BMC Genomics

Table 2 Top 15 genes identified by ratio from the array dataset

UG cluster ID	SwissProt Accession	Gene name	MFS NI	UC NI	Ratio MFS/UC	q-value
Hs.146688	PTGES:O14684	Prostaglandin E synthase	185	108	1.71	1.36E-03
Hs.90303	TSC2:P49815	Tuberous sclerosis 2	60	37	1.64	1.26E-04
Hs.1872	PCK1:P35558	Phosphoenolpyruvate carboxykinase 1	249	157	1.59	4.11E-03
Hs.310545	SYT1:P21579	Synaptotagmin I	109	69	1.57	2.60E-03
Hs.144700	EFNB1:P98172	Ephrin-B1	296	191	1.56	4.84E-03
Hs.334534	GNS:P15586	Glucosamine (N-acetyl)-6-sulfatase	173	112	1.54	5.23E-05
Hs.386283	ADAM12:O43184	Meltrin L	44	73	1.65^-1	5.08E-09
Hs.516646	CREB1:P16220	CAMP responsive element BP 1	193	339	1.76^-1	1.96E-05
Hs.489142	COL1A2:P08123	Collagen, type I, alpha 2	3663	6582	1.80^-1	4.48E-06
Hs.146447	FBN1:P35555	Fibrillin 1	124	233	1.89^-1	2.52E-10
Hs.250581	SMARCD2:Q92925	SWI/SNF D2	1532	2963	1.93^-1	5.99E-06
Hs.432862	MARCH-VI:O60337	RING-CH protein VI	2091	4245	2.03^-1	4.97E-09
Hs.55967	SHOX2:O60902	Short stature homeobox 2	58	137	2.38^-1	1.13E-12
Hs.443625	COL3A1:P02461	Collagen, type III, alpha 1	638	1538	2.41^-1	2.06E-04
Hs.252418	ELN:P15502	Elastin	35	117	3.34^-1	2.19E-08

Unigene ID identifies significant, differentially expressed genes based on expression ratio criteria. The top 6 down regulated and 9 up regulated genes are included. The normalized intensity (NI) from the phosphorimager scan is listed to give a sense of the expression range. The q values are computed based on t test p values. In this and subsequent tables, we show all ratios less than 1 as reciprocals. The entire 4132 gene list has been deposited into GEO (the Gene Expression Omnibus), accession number GSE8759.

ISSN: 1471-2164