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Table 1 Proteins in the Interaction Network

From: Comparison of the contributions of the nuclear and cytoplasmic compartments to global gene expression in human cells

Name

Description

Go Component

Go Process

AHR

aryl hydrocarbon receptor

nucleus

cell cycle;response to stress;apoptosis

AHSA1

AHA1, activator of heat shock 90 kDa ATPase homolog 1 (yeast)

ER;cytoplasm

response to stress;protein folding

APEX1

APEX nuclease (multifunctional DNA repair enzyme) 1

nucleus;ER;ribosom

base-excision repair;DNA repair

CCNT1

cyclin T1

nucleus

cytokinesis;regulation of cell cycle

G22P1

X-ray repair in Chinese hamster cells 6

nucleus

double-strand break;DNA repair

HIPK2

homeodomain interacting protein kinase 2

nucleus;nuclear body;cytoplasm

apoptosis;reg. of cell cycle

HSP90A1

heat shock 90 kDa protein 1, alpha

cytosol

mitochondrial transport;protein refolding

MITF

microphthalmia-associated transcription factor

nucleus

regulation of transcription; melanocyte differentiation

NUDCD3

NudC domain containing 3

NONE

NONE

PIAS1

protein inhibitor of activated STAT, 1

nucleus

ubiquitin cycle;regulation of transcription

PTEN1

phosphatase and tensin homolog (mutated in cancers 1)

cytoplasm

negative reg. of cell cycle;induction of apoptosis

SET

SET translocation (myeloid leukemia-associated)

ER;perinuclear region;nucleus

nucleocytoplasm transport;DNA replic.;nucleosome assembly

SUMO1

SMT3 suppressor of mif two 3 homolog 1 (yeast)

nucleus

ubiquitin cycle;protein modification;protein sumoylation

SUMO2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

nucleus

ubiquitin cycle;protein modification

SUMO3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

kinetochore

ubiquitin cycle;protein modification

TERT

telomerase reverse transcriptase

chromosome, telomeric region;nucleus

RNA-dependent DNA replication;telomere maintenance

TRADD

TNFRSF1A-associated via death domain

NONE

induction of apoptosis

TXN

thioredoxin

NONE

electron transport;cell-cell signaling;cell motility;cell prolif.

UBE2I

ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)

NONE

ubiquitin cycle;protein modification

XRCC1

X-ray repair in Chinese hamster cells 1

intracellular;nucleus

single strand break repair