Comparative genomic analysis of Tropheryma whipplei strains reveals that diversity among clinical isolates is mainly related to the WiSP proteins

Table 1 T. whipplei isolates used in this study and percentage of conserved CDSs identified through CGH analysis

Isolate designation	Sample origin	Clinical manifestations	Patient (sex, age)	Geographical origin	% conserved CDSs
Twist	Aortic valve	EW	M42	Canada	100.00
Endo 5	Heparinized blood	EW	M61	France	99.63
Endo 7	Aortic valve	EW	M67	Portugal	99.75
Slow 1B	Faeces	CWD, digestive relapse	F34	France	99.88
Slow 2	Duodenal biopsy	CWD	F70	France	99.50
ART 1	Synovial fluid	CWD	M68	France	99.13
Neuro 1	Cerebrospinal fluid	CWD, neurologic relapse	M57	Germany	99.88
Neuro 2	Cerebrospinal fluid	CWD with neurologic involvement	F40	France	99.63
Dig 7	Heparinized blood	CWD	M64	France	99.00
Dig 9	Heparinized blood	CWD	M35	France	99.38
Dig 10	Cerebrospinal fluid	CWD with neurologic involvement	M46	Germany	99.63
Dig ADP 11	Mesenteric lymph node	CWD	M56	France	99.50
Dig Neuro 14	Cerebrospinal fluid	CWD with neurologic involvement	M50	Germany	99.88
Dig 15	Cerebrospinal fluid	CWD with neurologic involvement	M60	Germany	97.76
Dig Musc 17	Muscle	CWD	F73	France	99.25
Dig Neuro 18	Cerebrospinal fluid	CWD with neurologic involvement	M68	France	99.25

ISSN: 1471-2164