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Table 1 The top 5 most significant Gene Ontology (GO) terms significantly enriched in K-means clusters 1 to 5

From: Androgen-induced masculinization in rainbow trout results in a marked dysregulation of early gonadal gene expression profiles

KM

Term (GO ID)

P-Value

RE

(n/N)

1 to 5

regulation of progression through cell cycle (74)

0.0002

1.36

(50/62)

 

nucleolus (5730)

0.0012

1.49

(23/26)

 

mitotic cell cycle (278)

0.0016

1.37

(35/43)

 

macromolecule biosynthesis (9059)

0.0029

1.22

(74/102)

 

protein biosynthesis (6412)

0.0031

1.23

(68/93)

1

cytoplasmic membrane-bound vesicle (16023)

0.0063

3.00

(7/25)

 

telomere maintenance (723)

0.0071

6.40

(3/5)

 

ion homeostasis (50801)

0.0095

3.50

(5/15)

 

gastrulation (7369)

0.0147

3.90

(4/11)

 

digestion (7586)

0.0216

4.50

(3/7)

2

cellular respiration (45333)

0.0000

5.90

(7/8)

 

translation regulator activity (45182)

0.0000

3.20

(13/27)

 

aerobic respiration (9060)

0.0001

6.70

(5/5)

 

pyrophosphatase activity (16462)

0.0004

2.10

(21/68)

 

GTPase activity (3924)

0.0012

2.80

(10/24)

3

mitosis (7067)

0.0040

2.10

(12/26)

 

rRNA binding (19843)

0.0064

3.30

(5/7)

 

nuclear hormone receptor binding (35257)

0.0088

3.70

(4/5)

 

replication fork (5657)

0.0141

2.90

(5/8)

 

interphase of mitotic cell cycle (51329)

0.0154

2.10

(9/20)

4

hydrogen-transporting ATPase activity (46961)

0.0009

4.20

(6/10)

 

ATP biosynthesis (6754)

0.0018

3.90

(6/11)

 

cell growth (16049)

0.0053

3.30

(6/13)

 

transcription factor binding (8134)

0.0094

2.20

(10/32)

 

chromatin assembly (31497)

0.0169

3.50

(4/8)

5

ribosome (5840)

0.0000

3.40

(18/48)

 

ribonucleoprotein complex (30529)

0.0000

2.70

(26/88)

 

cytoplasm organization and biogenesis (7028)

0.0003

2.90

(12/37)

 

cytosolic large ribosomal subunit (5842)

0.0005

4.90

(6/11)

 

ribosome biogenesis and assembly (42254)

0.0006

2.90

(11/34)

  1. These GO terms were selected as the 5 most significant GO terms enriched in each K-means cluster (KM) 1 to 5 with a P-value < 0.05 and a relative enrichment RE > 2 (except for the analysis of the fusion of clusters 1 to 5). n/N: number of genes assigned with a specific GO term in the cluster (n) with regards to the number of all genes assigned with the same GO term in the 2,474 analyzed genes (N). Interesting GO terms in regard to gonad differentiation and development are underlined. Genes with GO terms in bold type are detailed in figures 3 to 5. GO categories containing fewer than 5 genes were excluded.
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BMC Genomics

ISSN: 1471-2164

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