Table 2 The top 5 most significant Gene Ontology (GO) terms significantly enriched in K-means clusters 6 to 13
KM | Term (GO ID) | P-Value | RE | (n/N) |
|---|---|---|---|---|
6 | cell surface (9986) | 0.0000 | 12.30 | (5/11) |
T cell activation (42110) | 0.0005 | 16.20 | (3/5) | |
immune response (6955) | 0.0015 | 4.50 | (6/36) | |
lipid binding (8289) | 0.0020 | 5.20 | (5/26) | |
neuron development (48666) | 0.0022 | 6.70 | (4/16) | |
7 | extracellular matrix (sensu Metazoa) (5578) | 0.0000 | 4.60 | (10/32) |
actin binding (3779) | 0.0002 | 4.50 | (8/26) | |
muscle contraction (6936) | 0.0004 | 6.70 | (5/11) | |
phosphate transport (6817) | 0.0006 | 8.40 | (4/7) | |
structural molecule activity (5198) | 0.0012 | 2.30 | (15/96) | |
8 | condensed chromosome (793) | 0.0005 | 15.50 | (3/5) |
response to endogenous stimulus (9719) | 0.0025 | 5.00 | (5/26) | |
DNA repair (6281) | 0.0061 | 5.20 | (4/20) | |
magnesium ion binding (287) | 0.0087 | 4.70 | (4/22) | |
chromosome (5694) | 0.0224 | 3.00 | (5/43) | |
9 | calcium ion binding (5509) | 0.0004 | 2.50 | (15/63) |
organ morphogenesis (9887) | 0.0006 | 2.60 | (13/52) | |
plasma membrane (5886) | 0.0011 | 2.10 | (18/90) | |
organ development (48513) | 0.0018 | 2.10 | (16/79) | |
structural constituent of cytoskeleton (5200) | 0.0020 | 4.80 | (5/11) | |
10 | urogenital system development (1655) | 0.0060 | 7.00 | (3/6) |
lipid binding (8289) | 0.0080 | 3.20 | (6/26) | |
response to temperature stimulus (9266) | 0.0100 | 6.00 | (3/7) | |
protein kinase binding (19901) | 0.0100 | 6.00 | (3/7) | |
circulation (8015) | 0.0152 | 5.20 | (3/8) | |
11 | metallopeptidase activity (8237) | 0.0013 | 5.40 | (5/12) |
proteolysis (6508) | 0.0016 | 2.40 | (13/69) | |
peptidase activity (8233) | 0.0022 | 2.50 | (12/63) | |
endopeptidase activity (4175) | 0.0079 | 2.50 | (9/47) | |
transcription from RNA polymerase II promoter (6366) | 0.0381 | 2.00 | (8/51) | |
12 | ligase activity, forming carbon-nitrogen bonds (16879) | 0.0050 | 3.00 | (7/21) |
metallopeptidase activity (8237) | 0.0061 | 3.80 | (5/12) | |
mRNA metabolism (16071) | 0.0165 | 2.10 | (10/44) | |
glutamine family amino acid biosynthesis (9084) | 0.0200 | 4.60 | (3/6) | |
regulation of RNA metabolism (51252) | 0.0322 | 3.90 | (3/7) | |
13 | steroid biosynthesis (6694) | 0.0020 | 10.80 | (3/9) |
sex differentiation (7548) | 0.0028 | 9.70 | (3/10) | |
transcription, DNA-dependent (6351) | 0.0050 | 2.30 | (11/156) | |
hormone metabolism (42445) | 0.0063 | 7.50 | (3/13) | |
DNA binding (3677) | 0.0071 | 2.20 | (11/163) |