CGH profile-based clustering of 102 strains included in this study. Although cluster analysis of 56 neuropathogenic strains produced 6 major lineages, inclusion of the 46 enteritis-control strains shows that these lineages are not exclusively comprised of neuropathogenic strains. Both types of strains can show substantial similarities in genomic background, which includes similarities at several hypervariable regions. The lineage (LIN) of the 56 neuropathogenic strains is shown. Highly similar enteritis-control/neuropathogenic strain pairs (boxes a through d) are shown in expanded form in Figure 3. Legend: Hypervariable loci (L – LOS locus; F – flagellar modification locus; C – capsular locus; R/M – restriction-modification locus); Strain sets (DG: Dutch GBS; DM: Dutch MFS; DE: Dutch enteritis; JG: Japanese GBS; JM: Japanese MFS; JE: Japanese enteritis; CG: Curaçao GBS; CE: Curaçao enteritis).