Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity

Table 1 Genes with absence rates that differ between enteritis-control strains compared to neuropathogenic strains

Gene name	Proposed function	Neuropathogenic strains (n = 32)		Enteritis-control strains ¹(n = 32)		p-value²
		Absent	Absence rate (%)	Absent	Absence rate (%)
Cj1421c	Capsule biosynthesis ³	0	0	7	21.9	0.0108
fcl (Cj1428c)	Capsule biosynthesis ³	9	28.13	18	56.3	0.0420
Cj1135 ⁴	One-domain glucosyl transferase ³	32	100	26	81.3	0.0242
cgtA ⁵	N-acetyl galactosaminyl transferase	3	9.37	17	53.13	0.0003
neuA1 ⁵	CMP-NeuNAc synthetase,	3	9.37	14	43.75	0.0038
orf11 ⁵	Sialic acid acetyl transferase	3	9.37	13	40.63	0.0081

¹ Due to the smaller sample size of enteritis-control strains assayed using the newer version of our microarray, 8 enteritis-control strains from unrelated strain collections were randomly selected and included in this group.
² p-value based on 2-tailed Fisher's Exact Test
³ Proposed function obtained from [48]
⁴ Gene from strain ATCC 43431 (HS:3 type strain)
⁵ Gene from strain ATCC 43446 (HS:19 type strain)

ISSN: 1471-2164