Figure 6

GenMAPP pathway showing changes in expression of the transcription factor PPARα and fatty-acid degrading enzymes upon fasting. The upregulation of Pparα correlates with the upregulation of fatty acid β-oxidation involved Acadvl and Hadha at 12 h of fasting, while the prolonged fasting provokes downregulation of 6 genes involved in this process and return to control values of Pparα expression (regulation of PPARα target genes involved in other processes is shown in the additional file 2, supplementary table 3). Warm colors (from yellow to red) represent down-regulation, while cold (light blue to dark green) indicate an induction (with exact fold-change shown aside the boxes). Gray indicates no significant change. Genes not coupled to reporters on the array are shown in white. Genes represented by more than one sequence on the array are shown in a dash-lined box with the level of change depicted by a colored line surrounding the field.