Table 1 Top 70 known genes altered by TSA in MC3T3-E1 cells
From: Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors
Gene | Fold Change | Welch Test |
|---|---|---|
Induced | Â | Â |
   Ubiquitin carboxy-terminal hydrolase L1 | 12.66 | 6.79E-06 |
   Clusterin | 12.58 | 1.80E-05 |
   A kinase (PRKA) anchor protein (gravin) 12 | 9.431 | 1.06E-07 |
   Abhydrolase domain containing 3 | 9.089 | 1.36E-05 |
   Protease, serine, 35 | 9.058 | 3.48E-06 |
   Glutathione S-transferase, alpha 4 | 8.408 | 3.35E-08 |
   Amphiregulin | 7.100 | 2.57E-06 |
   Rab40b, member RAS oncogene family | 6.904 | 1.16E-06 |
   Thioredoxin interacting protein | 6.865 | 1.61E-06 |
   Apolipoprotein L, 2 | 6.604 | 0.001083 |
   Laminin, alpha 1 | 5.616 | 1.70E-04 |
   Solute carrier family 9, isoform 3 regulator 1 | 5.565 | 2.32E-05 |
   Growth arrest and DNA-damage-inducible 45 alpha | 5.422 | 3.67E-06 |
   Insulin-like 6 | 5.418 | 6.71E-05 |
   Thrombospondin 1 | 5.374 | 1.07E-04 |
   Aldehyde dehydrogenase family 1, subfamily A7 | 5.359 | 4.73E-04 |
   Erythrocyte protein band 4.1-like 5 | 5.266 | 6.39E-04 |
   Hemoglobin alpha, adult chain 1 | 5.119 | 2.93E-06 |
   Glutaminyl-peptide cyclotransferase (glutaminyl cyclase) | 5.046 | 1.22E-05 |
Suppressed | Â | Â |
   SMC4 structural maintenance of chromosomes 4-like 1 | -5.192 | 5.96E-04 |
   Kinesin family member 11 | -5.266 | 1.07E-08 |
   Lysyl oxidase | -5.284 | 1.66E-06 |
   Antigen identified by monoclonal antibody Ki 67 | -5.293 | 3.76E-04 |
   Prostaglandin F receptor | -5.296 | 6.12E-04 |
   Proteasome (prosome, macropain) subunit, beta type 10 | -5.362 | 4.16E-04 |
   Ubiquitin-conjugating enzyme E2C | -5.393 | 8.64E-06 |
   Cyclin B1, related sequence 1 | -5.408 | 1.21E-05 |
   Cytoskeleton associated protein 2 | -5.441 | 1.47E-07 |
   Polo-like kinase 4 | -5.456 | 1.03E-08 |
   Chromodomain helicase DNA binding protein 3 | -5.528 | 6.74E-04 |
   Hyaluronan mediated motility receptor (RHAMM) | -5.547 | 5.41E-04 |
   Kinesin family member 23 | -5.605 | 2.30E-06 |
   Epithelial membrane protein 3 | -5.606 | 3.65E-05 |
   Proteasome 26S subunit, ATPase 3, interacting protein | -5.623 | 5.01E-04 |
   Cell division cycle 2 homolog A (S. pombe) | -5.693 | 1.43E-05 |
   Formyltetrahydrofolate synthetase domain containing 1 | -5.725 | 1.96E-04 |
   Nucleolar and spindle associated protein 1 | -5.780 | 1.81E-05 |
   Centromere autoantigen A | -5.840 | 2.79E-04 |
   Fibroblast growth factor 7 | -5.856 | 6.42E-06 |
   c-Fos induced growth factor | -5.931 | 1.99E-04 |
   High mobility group box 2 | -6.108 | 2.44E-08 |
   Similar to G2/mitotic-specific cyclin B1 | -6.166 | 1.07E-05 |
   Cyclin A2 | -6.311 | 3.35E-08 |
   Cell division cycle associated 2 | -6.395 | 3.47E-05 |
   Calmodulin-like 4 | -6.400 | 7.64E-04 |
   Heat shock protein, alpha-crystallin-related, B6 | -6.401 | 1.69E-04 |
   Mannan-binding lectin serine protease 1 | -6.413 | 3.19E-05 |
   UDP glycosyltransferase 1 family, polypeptide A6 | -6.498 | 8.67E-04 |
   Calmodulin binding protein 1 | -6.501 | 1.68E-08 |
   Aurora kinase B | -6.531 | 1.74E-05 |
   PDZ binding kinase | -6.548 | 3.16E-08 |
   Minichromosome maintenance deficient 5 | -6.613 | 6.08E-08 |
   Interleukin 1 receptor-like 1 | -6.641 | 6.40E-08 |
   RAD51 associated protein 1 | -6.877 | 9.26E-05 |
   Centromere protein E | -6.911 | 3.17E-04 |
   F-box only protein 5 | -7.052 | 1.79E-07 |
   Serine/threonine kinase 6 | -7.090 | 1.10E-07 |
   Stem cell growth factor | -7.199 | 6.95E-05 |
   Proline 4-hydroxylase, alpha polypeptide III | -7.383 | 3.66E-07 |
   Cell division cycle 20 homolog | -7.469 | 1.27E-04 |
   Asporin | -7.618 | 6.15E-04 |
   Glutathione peroxidase 7 | -8.216 | 1.26E-07 |
   Polo-like kinase 1 | -8.301 | 9.95E-06 |
   Sushi-repeat-containing protein | -8.701 | 5.38E-08 |
   Ribonucleotide reductase M2 | -9.796 | 2.00E-04 |
   Chromosome condensation 1-like | -9.845 | 6.69E-04 |
   Histone 1, H2ad | -10.21 | 4.61E-06 |
   Procollagen, type III, alpha 1 | -10.44 | 6.38E-04 |
   Matrix metalloproteinase 13 | -11.09 | 3.70E-05 |
   Thymidine kinase 1 | -16.96 | 2.88E-05 |