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Table 4 Genes differentially regulated by all three HDIs

From: Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

Gene Description TSA MS-275 VPA
Induced Fold Change
   Thioredoxin interacting protein 6.865 1.530 1.404
   Solute carrier family 9, isoform 3 regulator 1 5.565 2.477 2.203
   Glutaminyl-peptide cyclotransferase (glutaminyl cyclase) 5.046 2.387 2.334
   Sorbitol dehydrogenase 1 4.455 2.431 2.328
   Histocompatibility 2, Q region locus 5 4.009 1.634 1.820
   Phosphomannomutase 1 3.895 1.902 1.808
   RAB3D, member RAS oncogene family 3.717 1.528 1.742
   Cbp/p300-interacting transactivator 3.458 1.658 1.321
   Protease, serine, 11 3.326 1.836 1.744
   Syntaxin 11 2.488 1.942 1.750
   Protein phosphatase 1, regulatory (inhibitor) subunit 14c 2.484 1.347 1.830
   Lysosomal-associated protein transmembrane 4B 2.366 1.503 1.637
   Similar to normal mucosa of esophagus specific gene 1 2.099 2.157 1.930
   F-box and leucine-rich repeat protein 16 2.019 1.746 1.561
   HIV-1 Rev binding protein 1.953 1.406 1.414
   Heat shock 70 kDa protein 5 binding protein 1 1.946 1.358 1.589
   Cysteine rich protein 2 1.929 1.847 1.773
   Asparagine synthetase 1.597 1.451 1.248
   Serum deprivation response 1.485 1.517 1.676
   Thymus cell antigen 1, theta 1.419 1.638 1.676
   Ribonuclease, RNase A family 4 1.341 1.341 1.529
Suppressed    
   Interleukin 1 receptor-like 1 -1.634 -2.035 -1.831
   Low density lipoprotein receptor -2.487 -1.282 -1.377
   Proteolipid protein 2 -2.717 -1.274 -1.233
   PHD finger protein 15 -4.100 -1.498 -1.613
   Vesicle-associated membrane protein 8 -4.130 -1.417 -1.500
   Proteasome (prosome, macropain) subunit, beta type 10 -5.362 -2.063 -2.035
   Chromosome condensation 1-like -7.016 -1.514 -1.721
   Glutathione peroxidase 7 -8.216 -1.768 -1.972
  1. All genes were present at a FDR of 0.01 (99% confidence) relative to the vehicle control, DMSO.