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Table 5 Genes differentially regulated more than two-fold by all three HDIs

From: Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

Gene Description TSA MS-275 VPA
Induced Fold Change
   A kinase anchor protein 12 (Akap12) 9.5 2.0 2.6
   Glutaminyl-peptide cyclotransferase (Qpct)* 5.0 2.4 2.3
   Glutathione S-transferase, alpha 4 (Gsta4) 8.5 2.3 3.1
   Ral GEF with PH domain and SH3 binding motif 2 (Ralgps2) 2.2 2.0 2.1
   Solute carrier family 9, isoform 3 regulator 1 (Slc9a3r1)* 5.6 2.5 2.2
   Sorbitol dehydrogenase 1 (Sdh1)* 4.5 2.4 2.3
Suppressed    
   Adaptor-related protein complex AP-4, sigma 1 (Ap4s1) -4.9 -2.5 -2.1
   Proteasome (prosome, macropain) subunit, beta type 10 (Psmb10)* -5.4 -2.1 -2.0
  1. All genes were present at a FDR of 0.05 (95% confidence) relative to the vehicle control, DMSO. An asterisk (*) indicates genes present at a FDR of 0.01 (99% confidence).