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Table 6 Growth factor and growth factor receptor genes regulated by HDIs

From: Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

 

MC3T3 Cells Microarray

Primary Osteoblasts qRT-PCR

Growth factor/receptor

TSA

MS-275

VPA

TSA

VPA

 

Fold Change

Amphiregulin

7.10

2.74

1.82

24.8

2.56

Brain-derived neurotrophic factor

2.51

1.66

1.77

ND

ND

Fibroblast growth factor 7

-5.80

-1.10

-1.17

-29.9

1.05

Frizzled 1

-2.17

-1.25

-1.24

-2.53

-1.44

Frizzled 4

2.23

1.37

1.53

1.79

2.57

Interleukin 1 receptor-like 1

-1.63

-2.04

-1.83

-52.1

1.04

Interleukin 17 receptor c

-2.62

-1.50

-1.43

ND

ND

Smoothened

-2.60

-1.53

-1.17

ND

ND

  1. Cells were incubated with HDIs for 18 hr. All genes were present at a FDR of 0.05 (95% confidence) relative to the vehicle control, DMSO. ND, not determined.