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Table 6 Growth factor and growth factor receptor genes regulated by HDIs

From: Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors

  MC3T3 Cells Microarray Primary Osteoblasts qRT-PCR
Growth factor/receptor TSA MS-275 VPA TSA VPA
  Fold Change
Amphiregulin 7.10 2.74 1.82 24.8 2.56
Brain-derived neurotrophic factor 2.51 1.66 1.77 ND ND
Fibroblast growth factor 7 -5.80 -1.10 -1.17 -29.9 1.05
Frizzled 1 -2.17 -1.25 -1.24 -2.53 -1.44
Frizzled 4 2.23 1.37 1.53 1.79 2.57
Interleukin 1 receptor-like 1 -1.63 -2.04 -1.83 -52.1 1.04
Interleukin 17 receptor c -2.62 -1.50 -1.43 ND ND
Smoothened -2.60 -1.53 -1.17 ND ND
  1. Cells were incubated with HDIs for 18 hr. All genes were present at a FDR of 0.05 (95% confidence) relative to the vehicle control, DMSO. ND, not determined.