Effect of treatment with Fibrates on the cytotoxicity and ketone body release in response to palmitate. (a) Effect on cytotoxicity. Cells were pretreated with 100 uM clofibrate or ciprofibrate for 24 h, followed by treatment with 0.7 mM palmitate in the presence of 100 uM clofibrate or ciprofibrate for 48 h. The LDH released after 48 h was measured. (b) Effect on beta-hydroxybutyrate release. Cells were cultured as in (a) and the beta-hydroxybutyrate released into the medium was measured enzymatically. Data presented as mean +/- s.d. of 3 independent experiments. , significantly lower than palmitate-treated cells (p < 0.01).