Figure 6
From: The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia
Ischemia blunts the gene expression differences in CA3 and CA1. A, Box-Whisker plot showing the narrowing of CA3/CA1 ratios in ischemic vs. naive animals. B, Plotting CA3/CA1 ratios in ischemia vs. sham reveals deviation from the diagonal. Difference ratios are attenuated by ischemia regardless of preferential CA3 or CA1 expression (red: pfdr < 0.05). C, Inhibin beta A displays the highest change in preference between the native and ischemic state. The gene expression preference actually reverses from higher expression in CA1 in the native brain to higher expression in CA3 in the ischemic state. Verification with quantitative PCR shows comparable values to the array-derived ratios.