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Table 5 Frame disruption placement and nonsense-mediated decay

From: Frame disruptions in human mRNA transcripts, and their relationship with splicing and protein structures

Type of initial frame disruption Alignment verification NMD or non-NMD region *   
   Observed [NMD : non-NMD] Expected [NMD : non-NMD] Significance
Frameshift All cases 159 : 188 294.9 : 52.1 †††
  Cases with verifying alignments 122 : 159 206.6 : 74.4 †††
Stop codon All cases 43 : 30 42.9 : 30.1 N.S.
  Cases with verifying alignments 22 : 17 17.5 : 21.5 N.S.
Frameshift or stop codon All cases 201 : 218 344.5 : 74.5 †††
  Cases with verifying alignments 141 : 184 232.0 : 93.0 †††
  Cases with verifying alignments (without 'probable UTR features') 87 : 122 111.5 : 97.5 †††
  1. * Ratios are for numbers expected or observed in NMD regions versus non-NMD ones. Expectations and tests are performed as for Table 1.