Figure 3

Experiment clustering with topography controlled (A) – versus previous (B) [8] gene set. Hierarchical clustering analyses of microarray experiments using the new topology-independent AR gene list (A) and our previous gene list [8] that did not control for topology of biopsy location (B). In each of the two clusters A and B, the microarray experiments used to generate the underlying list of significant genes by SAM were removed before clustering resulting 57 remaining experiments in (A) and 58 in (B), respectively. The color code is the same as in Fig. 2. Based on the previous gene set, several highly virilized AIS 2 patients and normal scrotal fibroblasts were incorrectly classified female.