Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome

Table 2 Biological processes

Biological process	Detected number of genes in SAM list	Expected number of genes based on NCBI reference list	P-value
Cell proliferation and differentiation	40	18.46	0.00001
Intracellular signaling cascade	35	15.59	0.00001
Protein phosphorylation	28	12.07	0.00005
Protein modification	40	20.81	0.00008
Developmental processes	61	37.57	0.00013
Biological process unclassified	157	193.59	0.00024
Cell cycle control	18	7.16	0.00041
Cell structure and motility	36	20.29	0.00076
Signal transduction	86	61.52	0.0008
Extracellular matrix protein-mediated signaling	6	1.09	0.00091

AR-dependent biological processes identified by PANTHER (Thomas et al. 2003) [11] as significantly over-represented in the SAM-list compared to the NCBI human reference gene list (table limited to genes with p < 0.001)

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