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Table 3 Cellular pathways

From: Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome

Cellular pathway Detected number of genes in SAM-list Expected number of genes based on NCBI reference list P-value
Angiogenesis 16 4.12 0.00001
Wnt signaling 20 6.71 0.00002
T cell activation 10 2.26 0.00012
Inflammation mediated by chemokine and cytokine signaling pathway 16 5.9 0.00038
Endothelin signaling pathway 8 1.84 0.00145
Muscarinic acetylcholine receptor 1 and 3 signaling pathway 5 0.81 0.00145
Integrin signaling pathway 12 4.44 0.00202
Alpha adrenergic receptor signaling pathway 4 0.53 0.00209
EGF receptor signaling pathway 8 2.56 0.00470
Unclassified 370 388.65 0.00476
Axon guidance mediated by semaphorins 5 1.15 0.00636
PDGF signaling pathway 9 3.38 0.00781
Ras pathway 6 1.73 0.00852
  1. AR-dependent cellular pathways identified by PANTHER (Thomas et al. 2003) [11] as significantly over-represented in the SAM-list compared to the NCBI human reference gene list (table limited to genes with p < 0.01)