Table 1 Selection of genes differentially expressed in AML1-MTG16-positive cells versus AML1-MTG16-negative cells grown in the presence of IL-3.
From: A distinct epigenetic signature at targets of a leukemia protein
Affymetrix ID | NCBI acc. number | Gene Symbol | Gene Title | GO/Ingenuity annotations | Fold change |
|---|---|---|---|---|---|
1450042_at | BB322201 | Arx | aristaless related homeobox gene (Drosophila) | regulation of transcription | 16.4 |
1460300_a_at | NM_008523 | Ltk | leukocyte tyrosine kinase | kinase signaling pathway | 15.9 |
1423869_s_at | AF349659 | Txnrd3 | thioredoxin reductase 3 | electron transport | 12.9 |
1418796_at | NM_009131 | Scgf | stem cell growth factor | cell adhesion/cell proliferation | 9.6 |
1427329_a_at | AI326478 | Igh-6 | immunoglobulin heavy chain 6 (heavy chain of IgM) | immune response | 8.6 |
1418588_at | NM_009513 | Vmp | vesicular membrain protein p24 | --- | 7.4 |
1450652_at | NM_007802 | Ctsk | cathepsin K | proteolysis | 7.2 |
1428439_at | BG066220 | Nyren18-pending | NY-REN-18 antigen | --- | 6.4 |
1419416_a_at | NM_011244 | Rarg | retinoic acid receptor, gamma | regulation of transcription | 6.3 |
1426800_at | BM214169 | D330025I23Rik (Cbfb) | RIKEN cDNA D330025I23 gene (core-binding factor beta subunit) | regulation of transcription | 6.2 |
1419136_at | NM_134066 | Akr1c18 | aldo-keto reductase family 1, member C18 | electron transport | 6.1 |
1425432_at | AF260307 | Oprm | opioid receptor, mu | G-protein signaling pathway | 6.0 |
1418346_at | NM_013754 | Insl6 | insulin-like 6 | physiological processes | 6.0 |
1449426_a_at | NM_011922 | Anxa10 | annexin A10 | --- | 5.9 |
1423029_at | NM_008236 | Hes2 | hairy and enhancer of split 2 (Drosophila) | regulation of transcription | 5.8 |
1454007_a_at | AK020384 | Zfp142 | zinc finger protein 142 | electron transport | 5.8 |
1423313_at | BG070255 | Pde7a | phosphodiesterase 7A | signal transduction | 5.8 |
1451915_at | L20509 | Cct3 | chaperonin subunit 3 (gamma) | protein folding | 5.7 |
1452487_x_at | BB133664 | Pirb | paired-Ig-like receptor B | --- | 5.7 |
1422030_at | AF326316 | Atp6v0a4 | ATPase, H+ transporting, lysosomal V0 subunit A isoform 4 | ATP hydrolysis/proton transport | 5.6 |
1427753_at | Z95479 | Igh-4 | immunoglobulin heavy chain 4 (serum IgG1) | immune response | 5.5 |
1437235_x_at | BB218844 | Lpp | LIM domain containing preferred translocation partner in lipoma | cytoskeleton organization/transcriptional regulation | 5.4 |
1426938_at | BB627486 | Nova1 | neuro-oncological ventral antigen 1 | mRNA splicing | 5.0 |
1460416_s_at | M55219 | Csprs | component of Sp100-rs | G-protein signaling pathway | 4.9 |
1427884_at | AW550625 | Col3a1 | procollagen, type III, alpha 1 | cell adhesion | 4.9 |
1450453_a_at | NM_012065 | Pde6g | phosphodiesterase 6G, cGMP-specific, rod, gamma | vision | 4.8 |
1455957_x_at | AV034167 | Ceacam11 | CEA-related cell adhesion molecule 11 | --- | 4.7 |
1450215_at | NM_009038 | Rcvrn | recoverin | vision | 4.7 |
1452489_at | BC016258 | Vps11 | vacuolar protein sorting 11 (yeast) | protein transport | 4.4 |
1421705_at | NM_018732 | Scn3a | sodium channel, voltage-gated, type III, alpha polypeptide | ion transport | 4.4 |
1421375_a_at | NM_011313 | S100a6 | S100 calcium binding protein A6 (calcyclin) | cell proliferation | 4.4 |
1433658_x_at | AV300794 | Pcbp4 | poly(rC) binding protein 4 | apoptosis | 4.2 |
1418136_at | NM_009365 | Tgfb1i1 | transforming growth factor beta 1 induced transcript 1 | regulation of transcription | 4.2 |
1450629_at | AV114522 | Eplin-pending | epithelial protein lost in neoplasm | --- | 3.9 |
1455421_x_at | AW490145 | Clcn1 | chloride channel 1 | ion transport | 3.7 |
1418451_at | BB522409 | Gng2 | guanine nucleotide binding protein (G protein), gamma 2 subunit | G-protein signaling pathway | 3.7 |
1450709_at | NM_007851 | Defcr5 | defensin related cryptdin 5 | defense response | 3.5 |
1423561_at | AI838010 | Nell2 | nel-like 2 homolog (chicken) | cell adhesion | 3.4 |
1452279_at | BB800282 | Pfc | properdin factor, complement | complement activation | 3.4 |
1424531_a_at | BC010807 | Tcea3 | transcription elongation factor A (SII), 3 | regulation of transcription | 3.4 |
1419325_at | NM_019515 | Nmu | neuromedin | neuropeptide signaling pathway | 3.4 |
1422945_a_at | AI844677 | Kif5c | kinesin family member 5C | protein transport | 3.3 |
1460280_at | NM_010815 | Mona | monocytic adaptor | intracellular signaling cascade | 3.3 |
1448529_at | NM_009378 | Thbd | thrombomodulin | blood coagulation | 3.2 |
1449830_at | NM_013766 | Prlpi | prolactin-like protein I | --- | 3.2 |
1423596_at | BB528391 | Nek6 | NIMA (never in mitosis gene a)-related expressed kinase 6 | kinase signaling pathway/cell proliferation | 3.2 |
1450435_at | NM_008478 | Slc7a2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | amino acid transport | 3.2 |
1420373_at | BI249549 | Foxj2 | forkhead box J2 | regulation of transcription | 3.1 |
1436769_at | AV101011 | Psma1 | proteasome (prosome, macropain) subunit, alpha type 1 | ubiquitin-dependent protein catabolism | 3.1 |
1421778_at | NM_011911 | V1rb2 | vomeronasal 1, receptor B2 | chemosensory perception/G-protein signaling pathway | 3.0 |
1448416_at | NM_008597 | Mglap | matrix gamma-carboxyglutamate (gla) protein | --- | -3.0 |
1419012_at | NM_011766 | Zfpm2 | zinc finger protein, multitype 2 | regulation of transcription | -3.0 |
1449833_at | NM_011472 | Sprr2f | small proline-rich protein 2F | --- | -3.1 |
1424814_a_at | BC025541 | 9030625M01Rik (Bclg) | RIKEN cDNA 9030625M01 gene (apoptosis regulator Bclg) | apoptosis | -3.1 |
1417338_at | U03487 | Epb4.2 | erythrocyte protein band 4.2 | structural function | -3.3 |
1448152_at | NM_010514 | Igf2 | insulin-like growth factor 2 | cell proliferation | -3.6 |
1429947_a_at | AK008179 | Zbp1 | Z-DNA binding protein 1 | --- | -3.7 |
1420394_s_at | U05264 | Gp49b | glycoprotein 49 B | immune response? | -3.7 |
1424898_at | BC021154 | Slc10a1 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | ion transport | -3.8 |
1416822_at | BC013711 | Es2el | expressed sequence 2 embryonic lethal | --- | -4.0 |
1420779_at | NM_010213 | Fhl3 | four and a half LIM domains 3 | cytoskeleton organization | -4.3 |
1419124_at | NM_133829 | AW212394 | expressed sequence AW212394 | --- | -4.4 |
1425597_a_at | AW060288 | Qk | quaking | apoptosis | -4.6 |
1422416_s_at | NM_016983 | Vpreb2 | Pre-B lymphocyte gene 2 | hematopoiesis | -4.7 |
1425863_a_at | AF295638 | Ptpro | protein tyrosine phosphatase, receptor type, O | phosphatase signaling pathway | -4.8 |
1418177_at | AF233778 | Gabrg2 | gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2 | synaptic transmission | -4.8 |
1421309_at | NM_008598 | Mgmt | O-6-methylguanine-DNA methyltransferase | DNA repair | -8.2 |
1421288_at | NM_007975 | F2rl3 | coagulation factor II (thrombin) receptor-like 3 | blood coagulation/G-protein signaling pathway | -14.2 |
1449347_a_at | NM_021365 | Xlr4 | X-linked lymphocyte-regulated 4 | chromatin remodeling? | -16.9 |
1448511_at | NM_016933 | Ptprcap | protein tyrosine phosphatase, receptor type, C polypeptide-associated protein | phosphatase signaling pathway | -17.7 |
1421775_at | NM_010184 | Fcer1a | Fc receptor, IgE, high affinity I, alpha polypeptide | signal transduction | -27.2 |