Table 3 Selection of putative AML1-target genes downregulated in AML1-MTG16-positive cells versus AML1-MTG16-negative cells.
From: A distinct epigenetic signature at targets of a leukemia protein
Affymetrix ID | NCBI acc. number | Gene Symbol | Gene Title | GO/Ingenuity annotations | Fold change IL-3 | Fold change G-CSF |
|---|---|---|---|---|---|---|
1417338_at | U03487 | Epb4.2 | erythrocyte protein band 4.2 | structural function | -3.3 | --- |
1433888_at | AV343478 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | metabolism | --- | -3.5 |
1426868_x_at | AK003174 | Lmna | lamin A | cell morphology | --- | -3.5 |
1423292_a_at | BG072867 | Prx | periaxin | intracellular signaling cascade | --- | -3.6 |
1449891_a_at | NM_028523 | Esdn-pending | endothelial and smooth muscle cell-derived neuropilin-like molecule | --- | --- | -3.6 |
1425708_at | AF285585 | Rnf17 | ring finger protein 17 | --- | --- | -4.2 |
1419124_at | NM_133829 | AW212394 | expressed sequence AW212394 | --- | -4.4 | --- |
1425597_a_at | AW060288 | Qk | quaking | apoptosis | -4.6 | --- |
1419227_at | NM_009839 | Cct6b | chaperonin subunit 6b (zeta) | protein folding | --- | -5.0 |
1455853_x_at | BB768303 | 2700085A14Rik (Sas) | RIKEN cDNA 2700085A14 gene (Sarcoma amplified sequence) | cell proliferation/signal transduction | --- | -5.3 |
1422473_at | BM246564 | Pde4b | phosphodiesterase 4B, cAMP specific | signal transduction | --- | -7.8 |
1421309_at | NM_008598 | Mgmt | O-6-methylguanine-DNA methyltransferase | DNA repair | -8.2 | --- |
1421288_at | NM_007975 | F2rl3 | coagulation factor II (thrombin) receptor-like 3 | blood coagulation/G-protein signaling pathway | -14.2 | --- |
1449347_a_at | NM_021365 | Xlr4 | X-linked lymphocyte-regulated 4 | chromatin remodelling? | -16.9 | -34.4 |
1448511_at | NM_016933 | Ptprcap (1) | protein tyrosine phosphatase, receptor type, C polypeptide-associated protein | phosphatase signaling pathway | -17.7 | --- |
1419537_at | NM_031198 | Tcfec | transcription factor EC | regulation of transcription | --- | -20.6 |
1421775_at | NM_010184 | Fcer1a | Fc receptor, IgE, high affinity I, alpha polypeptide | signal transduction | -27.2 | --- |