Figure 7

BRCA1 mutation positive breast cancer sample analyzed using a tiling 32 K BAC array and an Agilent 244 K oligonucleotide CGH array. Correction lines for Median (orange), Lowess (green), and popLowess (red) normalization are superimposed in panels (e) and (f). Identified copy number populations are differentially colored in panels (g) and (h) according to size where yellow corresponds to the largest identified copy number population, red to the second largest, and green to the smallest. Data in panels (g) and (h) are centered on the middle population (a) Genome plot of un-normalized BAC data. (b) Genome plot of un-normalized Agilent data. (c) M-A plot of un-normalized BAC data. (d) M-A plot of un-normalized Agilent data. (e) Contour plot of copy number population enriched BAC data. (f) Contour plot of copy number population enriched Agilent data. (g) Genome plot of BAC data after popLowess. (h) Genome plot of Agilent data after popLowess.