Figure 9
From: Normalization of array-CGH data: influence of copy number imbalances
Use of sample adaptive gain/loss thresholds. Thresholds are applied to data from figure 7. (a) Copy number profile derived from BAC data for chromosome 4 after popLowess normalization with adaptive thresholds superimposed (± 0.372). (b) Copy number profile for chromosome 4 for data from panel (a) after smoothing (250 kBp) and new threshold estimate (± 0.176). (c) Copy number profile of Agilent data for chromosome 4 after popLowess normalization with adaptive thresholds superimposed (± 0.453). (d) Copy number profile for chromosome 4 for data from panel (c) after smoothing (50 kBp) and new threshold estimate (± 0.171).