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Table 3 Cytogenetic and molecular data for the 16 TEL/AML1 (ETV6/RUNX1)-positive patients

From: Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia

Patients TEL/AML1 (ETV6/RUNX1) Fusion gene RISK GROUP KARYOTYPE AML1(RUNX1) Copy-Number FISH TEL(ETV6) Deletion FISH
3 TEL/AML1 SR 45, XY, der(3)t(3;8),-8, add(12)p?12?13 3 YES
5 TEL/AML1 SR 46, XY 2 YES
9 NONE SR 53, XXY,+6,+10,+10,+14,+18,+?i(21q)[16]/46, XY[7] 4 NO
12 TEL/AML1 SR 46, XY 2 NO
13 TEL/AML1 SR 49, XX,+10,+15,+der(21)[1]/49, XX, idem, del(12)[6]/50XX, idem,+18[15]/50XX, idem, del(12),+18[2]/46XX[6] 3 YES
17 TEL/AML1 SR 47, XY, add(8p),-10, del(11q),+21,+mar[18]/46XY[4] 2 YES
18 TEL/AML1 HR 46, XY, add(19)(p or q) 2 YES
23 TEL/AML1 SR 50, XY,+8,?der(12),+21,+mar[4]/46XY)[26] 3 NO
32 TEL/AML1 HR 47, XY, t(3;14)(q?13;q?23),+21[18]/46, XY)[1] 4 NO
33 TEL/AML1 SR 46, XY 2 NO
35 TEL/AML1 SR 46, XY 2 NO
40 TEL/AML1 SR 45, X,-X, del(6)(q12qter) 2 YES
41 TEL/AML1 SR failure 2 NO
43 TEL/AML1 SR 46, X,?del(Xq)[20]/46, XX[16] 2 YES
47 TEL/AML1 SR 46, XY 2 NO
48 TEL/AML1 SR 46, XY[25] 2 NO
53 TEL/AML1 SR 46, XY, t(1;8)?(q31;q24)t(X;17)?(q21;p13) [20]/46, XY[3] 2 NO
  1. FISH experiments determined AML1 (RUNX1) gene copy number and revealed whether or not native TEL (ETV6) was deleted. Increased AML1 copy number was scored when present in more than 50% of the cell population.