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Table 3 Known protein-protein interaction for the prioritized candidate genes obtained using STRING

From: Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

  

Confidence Scores

Combined confidence score

Gene 1

Gene 2

Experimental

Knowledge

 

TGFB1 1,2

DCN 2

0.747

0.8

0.949

BRCA1

TP53 1

0.935

0

0.935

CTNNB1

CREBBP 2

0.912

0.9

0.991

MADH2 2

CREBBP 2

0.937

0

0.937

BCL2L1

TP53 1

0.935

0

0.935

CTNNB1

PITX2 2

0

0.9

0.9

PPARBP

TP53 1

0.935

0

0.935

CASP3 1

RB1

0.747

0.9

0.974

BMI1

PHC2

0.997

0

0.997

HMGB1

TP53 1

0.935

0

0.935

LDB1

LMO4

0.938

0

0.938

MADH2 2

TGFB2 1.2

0

0.9

0.9

EGFR 1

MAPK3 1,2

0

0.9

0.9

BRCA1

RB1

0.935

0

0.935

PITX2 2

LDB1

0

0.9

0.9

RXRA

CREBBP 2

0.03

0.9

0.903

TP53 1

CREBBP 2

0.983

0.9

0.998

CTNNB1

GJA1

0

0.9

0.9

PITX2 2

CREBBP 2

0

0.9

0.9

VEGF

ARNT

0

0.9

0.9

  1. The available evidence for the most significant interactions as well as the confidence score assigned for the interactions are shown
  2. 1 Members of/linked to the MAPK signalling pathway
  3. 2 Members of/linked to the TGF-β signalling pathway
  4. 3Members of/linked to the Hedgehog signalling pathway
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BMC Genomics

ISSN: 1471-2164

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