Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

BMC Genomics

Table 4 Biological pathways significantly over-represented among the top-ranked candidate genes

Pathway	Gene Count	P-value¹	P-value²
TGF-b signaling pathway	9	0.0000067	0.00001
Hedgehog signaling pathway	7	0.000038	0.000036
MAPK signaling pathway	13	0.000078	0.0006
Adherens junction	7	0.00035	0.00051
Cell cycle	8	0.00036	0.0012
Neurodegenerative disorders	5	0.00075	0.0023
Regulation of actin cytoskeletan	9	0.0035	0.014
Focal adhesion	9	0.004	0.022
Gap junction	6	0.0059	0.0079
Cytokine-cytokine receptor interaction	9	0.011	0.0017
Epithelial cell signaling in H. Pylori infection	4	0.018	0.029

The gene count indicates how many genes from a particular pathway were present in the candidate gene list of 87 genes. Note that varying P-values were obtained depending on the background list used
¹P-value obtained using the Homo sapiens gene list as a background list to the top-ranked candidate genes
²P-value obtained using the original candidate gene list as a background list to the top-ranked candidate genes

ISSN: 1471-2164