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Table 6 Pairs of promoter elements found to be enriched in the target promoter set relative to the background promoter set

From: Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

Pairs of promoter elements ORI TAR (%) BCG (%) Probability of finding PE in target set Probability of finding PE in background set TAR (n) BCG (n) TAR Total BCG Total P-value
-1 MZF1/+1 E2F 17.1036 6.62 1.47 0.00007 0.00002 36 151 544 10255 0.000003
-1 LEF1/-1 Pax-4 14.6726 6.62 1.77 0.00007 0.00002 36 182 544 10255 0.000254
-1 C/EBP/+1 VDR 10.1454 6.43 1.85 0.00006 0.00002 35 190 544 10255 0.002385
+1 C/EBP/+1 VDR 9.1022 6.99 2.42 0.00009 0.00003 38 248 544 10255 0.041880
-1 MAZ/-1 VDR 9.0220 9.19 2.89 0.00015 0.00005 50 296 544 10255 0.000012
-1 MZF1/-1 MZF1 8.4560 5.51 1.6 0.00007 0.00003 30 164 544 10255 0.039710
-1 ETF/-1 VDR 7.6725 7.54 2.68 0.00011 0.00004 41 275 544 10255 0.023710
-1 AP-2/-1 ETF 6.8853 12.87 5.11 0.00023 0.00009 70 524 544 10255 0.000015
-1 MAZ/+1 Sp1 6.4534 9.56 2.63 0.00012 0.00007 52 270 544 10255 0.000000
-1 Spz1/-1 Spz1 6.0515 14.34 5.57 0.00021 0.00009 78 571 544 10255 <0.00001
-1 VDR/-1 Spz1 5.4345 14.34 6.54 0.00024 0.00010 78 671 544 10255 0.000429
-1 ETF/-1 E2F 5.4001 11.76 5.22 0.00020 0.00009 64 535 544 10255 0.007227
-1 Spz1/-1 VDR 5.2463 13.6 6.58 0.00025 0.00010 74 675 544 10255 0.013100
-1 VDR/+1 ZF5 4.4308 14.15 6.59 0.00018 0.00009 77 676 544 10255 0.001322
  1. The criteria for selecting pairs of PE as enriched was that it has to appear in at least 5% of the target promoter sequences and to have over-representation index (ORI) of at least 2. PE that appear in statistically significant proportion in the target set are denoted by + in the ORI column.