Figure 4

Comparison of NEAT1 and NEAT2/MALAT-1 between the human and mouse genomes. (A) The dot plot details the unspliced 8708 nt of the human NEAT2/MALAT-1 transcript as compared to the 6982 nt mouse Neat2/Malat-1 transcript and shows strong conservation across the length of the NEAT2/MALAT-1 transcript. (B) The dot plot details the 3729 nt human NEAT1 transcript as compared to the 3177 nt mouse Neat1 transcript. Two islands of relatively high identity were identified by this comparison: nucleotide position 483–597 of human NEAT1 and 450–565 of mouse Neat1 show 87% identity, and nucleotide position 1113–1368 of human NEAT1 and 1013–1238 of mouse Neat1 show 80% identity. (C) A dot plot with identical parameters between the primary human and mouse XIST transcripts is shown for comparison. (D) A dot plot between human NEAT1 and NEAT2/MALAT-1 with a 50% identity cutoff demonstrates the lack of conservation between the transcripts.