Figure 4

Active and inactive copies of trans-sialidase. Comparison of two trans-sialidase repeat groups in DNPTrapper. Boxes indicate reads, colored dots indicate DNPs. Only part of the alignment is shown. The reads have been clustered in DNPTrapper based on their DNP content, with reads sharing similar DNP patterns being grouped together. The lower group contains a C – T base substitution (circled) that corresponds to a Tyr – His substitution in the protein, rendering this repeat copy to lose its trans-sialidase activity.