Figure 4

Identification of the NFkB+ISRE cis-regulatory module. Mean expression patterns after exposure to LPS (MmBMM dataset) were computed for three disjoint sets of genes – putative targets of each single element separately (604 NF-κB targets, 838 ISRE targets), and targets of both elements (55 genes), obtained by scanning the promoters of all the genes in the MmBMM dataset. Y-axis is average log₂ of induction fold relative to time 0. Genes whose promoters contain hits for both NF-κB and ISRE elements were more strongly induced by LPS than genes whose promoters contain a hit for only one of these two elements.