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Table 2 Stimulators used in the mouse MmBMM and MmRAW datasets

From: Functional genomic delineation of TLR-induced transcriptional networks

Agent Description Engaged TLR
LPS Lipopolysaccharide is a component of the bacterial cell wall (gram-negative bacteria) TLR4
PAM2 Synthetic diacylated lipopeptide (mimics bacterial lipoproteins) TLR2:6
PAM3 Synthetic triacylated lipopeptide (mimics bacterial lipoproteins) TLR1:2
PIC Polyinosine-polycytidylic acid (Poly I:C) is a synthetic mimic of viral double-stranded RNA TLR3
R848 Synthetic molecule of the imidazoquinoline family (mimics a viral product) TLR7/8
CpG Mimics bacterial and viral CpG DNA motifs TLR9